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Giorgio Lorenzo Colombo,1,2 Andrea Droghetti,3 Sergio Di Matteo,2 Henrike Ottenjann,4 Giacomo Matteo Bruno2,5 1Center of Pharmaceuticals Economics and Medical Technologies Evaluation, Department of Drug Sciences, University of Pavia, Pavia, Italy; 2S.A.V.E. Studi Analisi Valutazioni Economiche S.r.l., Health Economics & Outcomes Research, Milan, Italy; 3Candiolo Cancer Institute, FPO-IRCCS, Candiolo (TO), Italy; 4Medizin & Wort, Munich, Germany; 5Department of Drug Science, University of Pavia, Pavia, ItalyCorrespondence: Giorgio Lorenzo Colombo, Studi Analisi Valutazioni Economiche (S.A.V.E.), Via Previati 74, Milan, 20149, Italy, Tel +39 02 4851 9230, Fax +39 02 7396 0369, Email giorgio.colombo@savestudi.itBackground: The international scientific literature is systematically analyzed in this review over a period of nearly 10 years with respect to the use of the active hemostat and surgical sealant patch TachoSil, considering its economic effects. It`s an update of the first review published in 2014.Methods: A PubMed systematic literature review was done from Nov 2013 up to December 2022. Based on the criteria used to select, the papers were grouped in terms of study design, surgery type, reduction in the time to hemostasis, shorter hospital stay, fewer number of post-operative complications, and the impact of TachoSil to operative procedures.Results: Medical evidence of TachoSil is well documented, in different clinical studies and for several indications. In this second review 18 scientific papers were screened. In total data from 3.375 patients were analyzed, of whom 1.748 were treated with TachoSil. Nine of the 18 papers (50%) were classified as randomized clinical trials (RCTs). The time required for hemostasis following the administration of TachoSil was significantly shorter than that observed with other surgical treatment techniques, with a median time of up to four minutes. The reduction in post-operative complications was evaluated in 15 studies that were conducted on patients in a ... |