| Title: |
Molecular pathways in cancer-related inflammation |
| Authors: |
Mantovani, Alberto; Corsi, Massimiliano M.; Fumarulo, Ruggiero; Santoro, Giuseppe; Allavena, Paola; Dep Prete, Annalisa |
| Source: |
Biochemia Medica ; ISSN 1846-7482 (Online) ; ISSN 1330-0962 (Print) ; ISSN-L 1330-0962 ; Volume 21 ; Issue 3 |
| Publisher Information: |
Croatian society of medical biochemistry and laboratory medicine |
| Publication Year: |
2011 |
| Collection: |
Hrčak - Portal of scientific journals of Croatia / Portal znanstvenih časopisa Republike Hrvatske |
| Subject Terms: |
cancer-related inflammation; cytokines; chemokines; macrophages |
| Description: |
Accumulating evidence shows that chronic inflammation is associated to increased risk of cancer. An inflammatory component is present also in the microenvironment of tumours epidemiologically unre-lated to inflammation. Extensive investigations over the past decade have uncovered many of the important mechanistic pathways underlying cancer-related inflammation. Pathways linking inflamma-tion and cancer have been identified: an intrinsic one (driven by genetic events that cause neoplasia) and an extrinsic one (driven by inflammatory conditions which predispose to cancer). Smouldering inflammation is a component of the tumour microenvironment and is a recognized hallmark of cancer. Key orchestrators at the intersection of the intrinsic and extrinsic pathways include transcription fac-tors (e.g. Nuclear Factor kappa-B, NFκB) that modulate the inflammatory response through soluble mediators (cytokines, chemokines) and cellular components (e.g. tumor-associated macrophages), promoting tumorigenesis. NFκB aids in the proliferation and survival of malignant cells, promotes an-giogenesis and metastasis, subverts adaptive immunity, and alters responses to hormones and che-motherapeutic agents. Emerging evidence also suggests that persistent inflammation promotes ge-netic instability. Thus, cancer-related inflammation represents a target for innovative diagnostic and therapeutic strategies. |
| Document Type: |
text |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
https://hrcak.srce.hr/72947 |
| Availability: |
https://hrcak.srce.hr/72947; https://hrcak.srce.hr/file/108614 |
| Rights: |
info:eu-repo/semantics/openAccess ; Biochemia Medica is open access journal and all published articles are subject to CC-BY Creative Commons Attribution Licence which permits users to read, download, copy, distribute, print, search, or link to the full texts of these articles in any medium or format. Manuscript submission, article processing and publishing is free of charge and all copyrights to the manuscript are transferred to Biochemia Medica. The publisher (Croatian Society of Medical Biochemistry and Laboratory Medicine) has the right to reproduce and distribute the article in printed and electronic form. Journal is maintained and published with the financial support of the members of the Croatian Society of Medical Biochemistry and Laboratory Medicine (CSMBLM) and grants given by the Republic of Croatia’s Ministry of Science and Education. All Editorial work and peer-review are maintained voluntarily. Occasionally, Biochemia Medica may publish a promotional material and advertisement in order to promote sponsorship with emphasis on the special subjects from the field of Laboratory Medicine. |
| Accession Number: |
edsbas.FFF823FF |
| Database: |
BASE |