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Expression quantitative trait methylation analysis elucidates gene regulatory effects of DNA methylation: the Framingham Heart Study

Title: Expression quantitative trait methylation analysis elucidates gene regulatory effects of DNA methylation: the Framingham Heart Study
Authors: Amena Keshawarz; Helena Bui; Roby Joehanes; Jiantao Ma; Chunyu Liu; Tianxiao Huan; Shih-Jen Hwang; Brandon Tejada; Meera Sooda; Paul Courchesne; Peter J. Munson; Cumhur Y. Demirkale; Chen Yao; Nancy L. Heard-Costa; Achilleas N. Pitsillides; Honghuang Lin; Ching-Ti Liu; Yuxuan Wang; Gina M. Peloso; Jessica Lundin; Jeffrey Haessler; Zhaohui Du; Michael Cho; Craig P. Hersh; Peter Castaldi; Laura M. Raffield; Jia Wen; Yun Li; Alexander P. Reiner; Mike Feolo; Nataliya Sharopova; Ramachandran S. Vasan; Dawn L. DeMeo; April P. Carson; Charles Kooperberg; Daniel Levy
Source: Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Publisher Information: Nature Portfolio, 2023.
Publication Year: 2023
Collection: LCC:Medicine; LCC:Science
Subject Terms: Medicine; Science
Description: Abstract Expression quantitative trait methylation (eQTM) analysis identifies DNA CpG sites at which methylation is associated with gene expression. The present study describes an eQTM resource of CpG-transcript pairs derived from whole blood DNA methylation and RNA sequencing gene expression data in 2115 Framingham Heart Study participants. We identified 70,047 significant cis CpG-transcript pairs at p
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2045-2322
Relation: https://doaj.org/toc/2045-2322
DOI: 10.1038/s41598-023-39936-3
Access URL: https://doaj.org/article/c06dd3b583dc4254b2ae2dc78e88198e
Accession Number: edsdoj.06dd3b583dc4254b2ae2dc78e88198e
Database: Directory of Open Access Journals