PRDM16 expression is an independent prognostic factor in AML with the double-mutant NPM1/FLT3-ITD genotype
| Title: | PRDM16 expression is an independent prognostic factor in AML with the double-mutant NPM1/FLT3-ITD genotype |
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| Authors: | Sebastian Stasik; Jan-Niklas Eckardt; Christoph Röllig; Claudia D. Baldus; Hubert Serve; Carsten Müller-Tidow; Kerstin Schäfer-Eckart; Martin Kaufmann; Stefan W. Krause; Mathias Hänel; Andreas Neubauer; Gerhard Ehninger; Uwe Platzbecker; Martin Bornhäuser; Johannes Schetelig; Jan M. Middeke; Christian Thiede |
| Source: | Annals of Hematology, Vol 105, Iss 2, Pp 1-12 (2026) |
| Publisher Information: | Springer, 2026. |
| Publication Year: | 2026 |
| Collection: | LCC:Internal medicine |
| Subject Terms: | PRDM16 expression; Acute Myeloid Leukemia (AML); Clinical Outcome; Molecular associations; Internal medicine; RC31-1245 |
| Description: | Abstract PRDM16 (PR Domain Containing 16) is a transcription factor that plays a critical role in hematopoietic stem cell maintenance. In acute myeloid leukemia (AML), PRDM16 overexpression is linked to specific cytogenetic risk groups and poor prognosis. However, in NPM1-mutated AMLs, PRDM16 expression varies widely, with no consensus on its prognostic significance. To understand molecular and clinical associations of PRDM16 expression in this relevant subgroup, we screened 503 adult NPM1-mutant AML patients. High PRDM16 expression was associated with mutations in DNMT3A (57% vs 22%; p |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1432-0584 |
| Relation: | https://doaj.org/toc/1432-0584 |
| DOI: | 10.1007/s00277-026-06767-x |
| Access URL: | https://doaj.org/article/0d5690bcb48740468c5befaefdc9e716 |
| Accession Number: | edsdoj.0d5690bcb48740468c5befaefdc9e716 |
| Database: | Directory of Open Access Journals |