Reactive astrocytes transduce inflammation in a blood-brain barrier model through a TNF-STAT3 signaling axis and secretion of alpha 1-antichymotrypsin
| Title: | Reactive astrocytes transduce inflammation in a blood-brain barrier model through a TNF-STAT3 signaling axis and secretion of alpha 1-antichymotrypsin |
|---|---|
| Authors: | Hyosung Kim; Kun Leng; Jinhee Park; Alexander G. Sorets; Suil Kim; Alena Shostak; Rebecca J. Embalabala; Kate Mlouk; Ketaki A. Katdare; Indigo V. L. Rose; Sarah M. Sturgeon; Emma H. Neal; Yan Ao; Shinong Wang; Michael V. Sofroniew; Jonathan M. Brunger; Douglas G. McMahon; Matthew S. Schrag; Martin Kampmann; Ethan S. Lippmann |
| Source: | Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022) |
| Publisher Information: | Nature Portfolio, 2022. |
| Publication Year: | 2022 |
| Collection: | LCC:Science |
| Subject Terms: | Science |
| Description: | Inflammation of brain endothelial cells is seen in neurodegenerative conditions and in aging. Here the authors examine the role of astrocytes in blood brain barrier function using an iPSC-derived cell co-culture model. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2041-1723 |
| Relation: | https://doaj.org/toc/2041-1723 |
| DOI: | 10.1038/s41467-022-34412-4 |
| Access URL: | https://doaj.org/article/106dfd6155e1471aa3dfbd079fe49bd4 |
| Accession Number: | edsdoj.106dfd6155e1471aa3dfbd079fe49bd4 |
| Database: | Directory of Open Access Journals |