Clinical interrogation of TP53 aberrations and its impact on survival in patients with myeloid neoplasms
| Title: | Clinical interrogation of TP53 aberrations and its impact on survival in patients with myeloid neoplasms |
|---|---|
| Authors: | Jayastu Senapati; Sanam Loghavi; Guillermo Garcia-Manero; Guillin Tang; Tapan Kadia; Nicholas J. Short; Hussein A. Abbas; Naszrin Arani; Courtney D. DiNardo; Gautam Borthakur; Naveen Pemmaraju; Betul Oran; Elizabeth Shpall; Uday Popat; Richard Champlin; Sherry Pierce; Sankalp Arora; Ghayas Issa; Musa Yilmaz; Keyur Patel; Koichi Takahashi; Guillermo Montalban-Bravo; Danielle Hammond; Fadi G. Haddad; Farhad Ravandi; Hagop M. Kantarjian; Naval G. Daver |
| Source: | Haematologica, Vol 999, Iss 1 (2024) |
| Publisher Information: | Ferrata Storti Foundation, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Diseases of the blood and blood-forming organs |
| Subject Terms: | Diseases of the blood and blood-forming organs; RC633-647.5 |
| Description: | In myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) with TP53 aberrations, dissecting the interaction amongst patient, disease and treatment factors are important for therapeutic decisions and prognostication. This retrospective analysis included patients with newly diagnosed MDS (>5% blasts) and AML with TP53 mutation(s) treated at MD Anderson Cancer Center. We factored patient age, TP53 aberration burden, therapy intensity and use of venetoclax in the AML subgroup, and allogeneic hematopoietic stem cell transplantation (HSCT) to interrogate outcomes. TP53 was annotated as high-risk (TP53HR) if >1 mutation, one mutation + allelic deletion or a single mutation with variant allele frequency (VAF) ≥40%; TP53 low risk (TP53LR) included a single TP53 mutation VAF |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 0390-6078; 1592-8721 |
| Relation: | https://haematologica.org/article/view/11870; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721 |
| DOI: | 10.3324/haematol.2024.286465 |
| Access URL: | https://doaj.org/article/c199f306952c4b93a7c1924a4e39b1b0 |
| Accession Number: | edsdoj.199f306952c4b93a7c1924a4e39b1b0 |
| Database: | Directory of Open Access Journals |