| Title: |
Assessment of the Anti-Amyloidogenic Properties of Essential Oils and Their Constituents in Cells Using a Whole-Cell Recombinant Biosensor |
| Authors: |
Electra Stylianopoulou; Anastasia Daviti; Venetia Giourou; Eleni Gerasimidi; Anastasios Nikolaou; Yiannis Kourkoutas; Maria E. Grigoriou; Katerina E. Paleologou; George Skavdis |
| Source: |
Brain Sciences, Vol 14, Iss 1, p 35 (2023) |
| Publisher Information: |
MDPI AG, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| Subject Terms: |
α-synuclein; Parkinson’s disease; split-luciferase assay; Gaussia princeps; essential oils; citron; Neurosciences. Biological psychiatry. Neuropsychiatry; RC321-571 |
| Description: |
Essential oils exhibit numerous medicinal properties, including antimicrobial, anti-inflammatory and antioxidant effects. Recent studies also indicate that certain essential oils demonstrate anti-amyloidogenic activity against β-amyloid, the protein implicated in Alzheimer’s disease. To investigate whether the anti-aggregating properties of essential oils extend to α-synuclein, the protein involved in Parkinson’s disease, we constructed and employed a whole-cell biosensor based on the split-luciferase complementation assay. We validated our biosensor by using baicalein, a known inhibitor of α-synuclein aggregation, and subsequently we tested eight essential oils commonly used in food and the hygienic industry. Two of them, citron and sage, along with their primary components, pure linalool (the main constituent in citron essential oil) and pure eucalyptol (1,8-cineole, the main constituent in sage essential oil), were able to reduce α-syn aggregation. These findings suggest that both essential oils and their main constituents could be regarded as potential components in functional foods or incorporated into complementary Parkinson’s disease therapies. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2076-3425 |
| Relation: |
https://www.mdpi.com/2076-3425/14/1/35; https://doaj.org/toc/2076-3425 |
| DOI: |
10.3390/brainsci14010035 |
| Access URL: |
https://doaj.org/article/27d2df44f97d42b09e7d9c5fd2fa86fd |
| Accession Number: |
edsdoj.27d2df44f97d42b09e7d9c5fd2fa86fd |
| Database: |
Directory of Open Access Journals |