| Title: |
CINSARC in high‐risk soft tissue sarcoma patients treated with neoadjuvant chemotherapy: Results from the ISG‐STS 1001 study |
| Authors: |
Anna Maria Frezza; Silvia Stacchiotti; Frederic Chibon; Jean‐Michelle Coindre; Antoine Italiano; Cleofe Romagnosa; Silvia Bagué; Angelo Paolo Dei Tos; Luca Braglia; Emanuela Palmerini; Vittorio Quagliuolo; Javier Martin Broto; Antonio Lopez Pousa; Giovanni Grignani; Antonella Brunello; Jean‐Yves Blay; Robert Diaz Beveridge; Iwona Lugowska; Tom Lesluyes; Roberta Maestro; Franco Domenico Merlo; Paolo Giovanni Casali; Alessandro Gronchi |
| Source: |
Cancer Medicine, Vol 12, Iss 2, Pp 1350-1357 (2023) |
| Publisher Information: |
Wiley, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: |
chemotherapy; CINSARC; outcome; prognostication; sarcoma; Neoplasms. Tumors. Oncology. Including cancer and carcinogens; RC254-282 |
| Description: |
Abstract Background The Complexity INdex in SARComas (CINSARC) is a transcriptional signature derived from the expression of 67 genes involved in mitosis control and chromosome integrity. This study aims to assess CINSARC value of in an independent series of high‐risk patients with localized soft tissue sarcoma (STS) treated with preoperative chemotherapy within a prospective, randomized, phase III study (ISG‐STS 1001). Patients and Methods Patients with available pre‐treatment samples, treated with 3 cycles of either standard (ST) preoperative or histotype‐tailored (HT) chemotherapy, were scored according to CINSARC (low‐risk, C1; high‐risk, C2). The 10‐year overall survival probability (pr‐OS) according to SARCULATOR was calculated, and patients were classified accordingly (low‐risk, Sarc‐LR, 10‐year pr‐OS>60%; high‐risk, Sarc‐HR, 10‐year pr‐OS |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2045-7634 |
| Relation: |
https://doaj.org/toc/2045-7634 |
| DOI: |
10.1002/cam4.5015 |
| Access URL: |
https://doaj.org/article/c40f99d4dfaa49b68f9028cd3bb23f20 |
| Accession Number: |
edsdoj.40f99d4dfaa49b68f9028cd3bb23f20 |
| Database: |
Directory of Open Access Journals |