| Title: |
Epidemiology, risk factors and clinical course of SARS-CoV-2 infected patients in a Swiss university hospital: An observational retrospective study. |
| Authors: |
Jean Regina; Matthaios Papadimitriou-Olivgeris; Raphaël Burger; Marie-Annick Le Pogam; Tapio Niemi; Paraskevas Filippidis; Jonathan Tschopp; Florian Desgranges; Benjamin Viala; Eleftheria Kampouri; Laurence Rochat; David Haefliger; Mehdi Belkoniene; Carlos Fidalgo; Antonios Kritikos; Katia Jaton; Laurence Senn; Pierre-Alexandre Bart; Jean-Luc Pagani; Oriol Manuel; Loïc Lhopitallier |
| Source: |
PLoS ONE, Vol 15, Iss 11, p e0240781 (2020) |
| Publisher Information: |
Public Library of Science (PLoS), 2020. |
| Publication Year: |
2020 |
| Collection: |
LCC:Medicine; LCC:Science |
| Subject Terms: |
Medicine; Science |
| Description: |
BackgroundThis study aims to describe the epidemiology of COVID-19 patients in a Swiss university hospital.MethodsThis retrospective observational study included all adult patients hospitalized with a laboratory confirmed SARS-CoV-2 infection from March 1 to March 25, 2020. We extracted data from electronic health records. The primary outcome was the need to mechanical ventilation at day 14. We used multivariate logistic regression to identify risk factors for mechanical ventilation. Follow-up was of at least 14 days.Results145 patients were included in the multivariate model, of whom 36 (24.8%) needed mechanical ventilation at 14 days. The median time from symptoms onset to mechanical ventilation was 9·5 days (IQR 7.00, 12.75). Multivariable regression showed increased odds of mechanical ventilation with age (OR 1.09 per year, 95% CI 1.03-1.16, p = 0.002), in males (OR 6.99, 95% CI 1.68-29.03, p = 0.007), in patients who presented with a qSOFA score ≥2 (OR 7.24, 95% CI 1.64-32.03, p = 0.009), with bilateral infiltrate (OR 18.92, 3.94-98.23, pConclusionsThis study gives some insight in the epidemiology and clinical course of patients admitted in a European tertiary hospital with SARS-CoV-2 infection. Age, male sex, high qSOFA score, CRP of 40 mg/l or greater and a bilateral radiological infiltrate could help clinicians identify patients at high risk for mechanical ventilation. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1932-6203 |
| Relation: |
https://doaj.org/toc/1932-6203 |
| DOI: |
10.1371/journal.pone.0240781 |
| Access URL: |
https://doaj.org/article/4fd7aecb0ece4010acfdb3a1fcb173bb |
| Accession Number: |
edsdoj.4fd7aecb0ece4010acfdb3a1fcb173bb |
| Database: |
Directory of Open Access Journals |