| Title: |
Venetoclax-based salvage therapy as a bridge to transplant is feasible and effective in patients with relapsed/refractory AML |
| Authors: |
Julia M. Unglaub; Richard F. Schlenk; Jan Moritz Middeke; Stefan W. Krause; Sabrina Kraus; Hermann Einsele; Michael Kramer; Sven Zukunft; Joseph Kauer; Simon Renders; Elena Katelari; Christoph Schliemann; Caroline Pabst; Thomas Luft; Peter Dreger; Christoph Röllig; Martin Bornhäuser; Carsten Müller-Tidow; Tim Sauer |
| Source: |
Blood Advances, Vol 9, Iss 2, Pp 375-385 (2025) |
| Publisher Information: |
Elsevier, 2025. |
| Publication Year: |
2025 |
| Collection: |
LCC:Specialties of internal medicine |
| Subject Terms: |
Specialties of internal medicine; RC581-951 |
| Description: |
Abstract: The B-cell lymphoma 2 inhibitor venetoclax (VEN) in combination with hypomethylating agents has been approved for first-line treatment of patients with acute myeloid leukemia (AML) ineligible for intensive treatment. VEN-containing treatment strategies may also be effective in relapsed/refractory (R/R) AML; however, comparative studies with conventional therapies for fit patients as a bridge-to-transplant strategy are limited. Using propensity score matching (PSM), we compared 37 patients with R/R AML, who received VEN-based salvage therapy as bridge to allogeneic hematopoietic stem cell transplantation (allo-HCT), with 90 patients from the German Study Alliance Leukemia AML registry, who were treated with non–VEN-containing salvage therapy according to their treating physician’s choice (TPC). The overall response rate among VEN patients was higher than the TPC control cohort (62% vs 42%; P = .049). Overall, 73% of VEN-treated patients vs 63% of TPC patients were bridged to allo-HCT (P = .41). After a median follow-up of 34.3 months for the VEN and 21.0 months for the TPC cohort, the median overall survival (OS) were 15.8 months (95% confidence interval [CI], 10.6 to not evaluable) and 10.5 months (95% CI, 6.8-19.6; P = .15), respectively. PSM revealed a trend toward improved OS for VEN patients (hazard ratio, 0.70; 95% CI, 0.41-1.22; P = .20). Median event-free survival was significantly longer in the VEN cohort (8.0 months) than the TPC cohort (3.7 months; P = .006). Our data suggest that VEN-based salvage therapy is a safe and effective bridge to allo-HCT for this difficult-to-treat AML patient population. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2473-9529 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2473952924005585; https://doaj.org/toc/2473-9529 |
| DOI: |
10.1182/bloodadvances.2024013086 |
| Access URL: |
https://doaj.org/article/585e9ee4ea354e2d8b3c19eaa34854ed |
| Accession Number: |
edsdoj.585e9ee4ea354e2d8b3c19eaa34854ed |
| Database: |
Directory of Open Access Journals |