| Title: |
Epigenome-wide meta-analysis of prenatal vitamin D insufficiency and cord blood DNA methylation |
| Authors: |
Elizabeth W. Diemer; Johanna Tuhkanen; Sara Sammallahti; Kati Heinonen; Alexander Neumann; Sonia L. Robinson; Matthew Suderman; Jianping Jin; Christian M. Page; Ruby Fore; Sheryl L. Rifas-Shiman; Emily Oken; Patrice Perron; Luigi Bouchard; Marie France Hivert; Katri Räikköne; Jari Lahti; Edwina H. Yeung; Weihua Guan; Sunni L. Mumford; Maria C. Magnus; Siri Håberg; Wenche Nystad; Christine L. Parr; Stephanie J. London; Janine F. Felix; Henning Tiemeier |
| Source: |
Epigenetics, Vol 19, Iss 1 (2024) |
| Publisher Information: |
Taylor & Francis Group, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Genetics |
| Subject Terms: |
Vitamin D insufficiency; EWAS; PACE; DNA methylation; epigenetics; Vitamin D; Genetics; QH426-470 |
| Description: |
Low maternal vitamin D concentrations during pregnancy have been associated with a range of offspring health outcomes. DNA methylation is one mechanism by which the maternal vitamin D status during pregnancy could impact offspring’s health in later life. We aimed to evaluate whether maternal vitamin D insufficiency during pregnancy was conditionally associated with DNA methylation in the offspring cord blood. Maternal vitamin D insufficiency (plasma 25-hydroxy vitamin D [Formula: see text] 75 nmol/L) during pregnancy and offspring cord blood DNA methylation, assessed using Illumina Infinium 450k or Illumina EPIC Beadchip, was collected for 3738 mother–child pairs in 7 cohorts as part of the Pregnancy and Childhood Epigenetics (PACE) consortium. Associations between maternal vitamin D and offspring DNA methylation, adjusted for fetal sex, maternal smoking, maternal age, maternal pre-pregnancy or early pregnancy BMI, maternal education, gestational age at measurement of 25(OH)D, parity, and cell type composition, were estimated using robust linear regression in each cohort, and a fixed-effects meta-analysis was conducted. The prevalence of vitamin D insufficiency ranged from 44.3% to 78.5% across cohorts. Across 364,678 CpG sites, none were associated with maternal vitamin D insufficiency at an epigenome-wide significant level after correcting for multiple testing using Bonferroni correction or a less conservative Benjamini–Hochberg False Discovery Rate approach (FDR, p > 0.05). In this epigenome-wide association study, we did not find convincing evidence of a conditional association of vitamin D insufficiency with offspring DNA methylation at any measured CpG site. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1559-2308; 1559-2294 |
| Relation: |
https://doaj.org/toc/1559-2294; https://doaj.org/toc/1559-2308 |
| DOI: |
10.1080/15592294.2024.2413815 |
| Access URL: |
https://doaj.org/article/5e8e802a77ca43568fa7aaec9fcc5eb2 |
| Accession Number: |
edsdoj.5e8e802a77ca43568fa7aaec9fcc5eb2 |
| Database: |
Directory of Open Access Journals |