| Title: |
Echocardiographic phenotypes of diabetic myocardial disorder: evolution over 15 months follow-up in the ARISE-HF trial |
| Authors: |
Thomas H. Marwick; Carolyn Lam; Yuxi Liu; Stefano Del Prato; Julio Rosenstock; Javed Butler; Justin Ezekowitz; Nasrien E. Ibrahim; W. H. Wilson Tang; Faiez Zannad; Riccardo Perfetti; James L. Januzzi |
| Source: |
Cardiovascular Diabetology, Vol 24, Iss 1, Pp 1-11 (2025) |
| Publisher Information: |
BMC, 2025. |
| Publication Year: |
2025 |
| Collection: |
LCC:Diseases of the circulatory (Cardiovascular) system |
| Subject Terms: |
Diabetic myocardial disorder; Biomarkers; Systolic dysfunction; Diastolic dysfunction; Diseases of the circulatory (Cardiovascular) system; RC666-701 |
| Description: |
Abstract Background Diabetic myocardial disorder (DbMD, evidenced by abnormal echocardiography or cardiac biomarkers) is a form of stage B heart failure (SBHF) at high risk for progression to overt HF. SBHF is defined by abnormal LV morphology and function and/or abnormal cardiac biomarker concentrations. Objective To compare the evolution of four DbMD groups based on biomarkers alone, systolic and diastolic dysfunction alone, or their combination. Methods The Aldose Reductase Inhibition for Stabilization of Exercise Capacity in Heart Failure (ARISE-HF) trial was a Phase 3 randomised trial of an aldose reductase inhibitor in patients with well-controlled type 2 diabetes mellitus (T2DM). The 1858 potential participants (age 67 ± 7 years; 50% women) were screened for SBHF based on abnormal echocardiography or biomarkers (N-terminal pro-B-type natriuretic peptide ≥ 40 ng/L or high sensitivity cardiac troponin T ≥ 10 ng/L [women] and ≥ 16 ng/L [men]). Exercise capacity (peak VO2) was reduced in 669 with DbMD (age 68 ± 7, 50% women), and peak VO2 was reassessed at 15 months. Results The 1463 (79%) participants with DbMD were allocated to four clusters; 907 (49%) showed isolated elevation of cardiac biomarkers, 301 (16%) with systolic dysfunction/hypertrophy, 162 (9%) with diastolic dysfunction and 93 (5%) comprised an overlap cluster (combined diastolic, systolic or LV geometric abnormalities). Reduced VO2 ( |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1475-2840 |
| Relation: |
https://doaj.org/toc/1475-2840 |
| DOI: |
10.1186/s12933-024-02554-y |
| Access URL: |
https://doaj.org/article/69cd8eebcd0e41b9be9fefe255f8e5a0 |
| Accession Number: |
edsdoj.69cd8eebcd0e41b9be9fefe255f8e5a0 |
| Database: |
Directory of Open Access Journals |