| Title: |
CD200 receptor restriction of myeloid cell responses antagonizes antiviral immunity and facilitates cytomegalovirus persistence within mucosal tissue. |
| Authors: |
Gabrielle Stack; Emma Jones; Morgan Marsden; Maria A Stacey; Robert J Snelgrove; Paul Lacaze; Laura C Jacques; Simone M Cuff; Richard J Stanton; Awen M Gallimore; Tracy Hussell; Gavin W G Wilkinson; Peter Ghazal; Philip R Taylor; Ian R Humphreys |
| Source: |
PLoS Pathogens, Vol 11, Iss 2, p e1004641 (2015) |
| Publisher Information: |
Public Library of Science (PLoS), 2015. |
| Publication Year: |
2015 |
| Collection: |
LCC:Immunologic diseases. Allergy; LCC:Biology (General) |
| Subject Terms: |
Immunologic diseases. Allergy; RC581-607; Biology (General); QH301-705.5 |
| Description: |
CD200 receptor (CD200R) negatively regulates peripheral and mucosal innate immune responses. Viruses, including herpesviruses, have acquired functional CD200 orthologs, implying that viral exploitation of this pathway is evolutionary advantageous. However, the role that CD200R signaling plays during herpesvirus infection in vivo requires clarification. Utilizing the murine cytomegalovirus (MCMV) model, we demonstrate that CD200R facilitates virus persistence within mucosal tissue. Specifically, MCMV infection of CD200R-deficient mice (CD200R(-/-)) elicited heightened mucosal virus-specific CD4 T cell responses that restricted virus persistence in the salivary glands. CD200R did not directly inhibit lymphocyte effector function. Instead, CD200R(-/-) mice exhibited enhanced APC accumulation that in the mucosa was a consequence of elevated cellular proliferation. Although MCMV does not encode an obvious CD200 homolog, productive replication in macrophages induced expression of cellular CD200. CD200 from hematopoietic and non-hematopoietic cells contributed independently to suppression of antiviral control in vivo. These results highlight the CD200-CD200R pathway as an important regulator of antiviral immunity during cytomegalovirus infection that is exploited by MCMV to establish chronicity within mucosal tissue. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1553-7366; 1553-7374 |
| Relation: |
https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374 |
| DOI: |
10.1371/journal.ppat.1004641 |
| Access URL: |
https://doaj.org/article/e69f5ed2db144e32af2dee37e2b1a0ca |
| Accession Number: |
edsdoj.69f5ed2db144e32af2dee37e2b1a0ca |
| Database: |
Directory of Open Access Journals |