| Title: |
Head-to-head comparison of tau PET tracers [18F]PI-2620 and [18F]RO948 in non-demented individuals with brain amyloid deposition: the TAU-PET FACEHBI cohort |
| Authors: |
Matteo Tonietto; Oscar Sotolongo-Grau; Núria Roé-Vellvé; Santiago Bullich; Juan Pablo Tartari; Ángela Sanabria; Ainhoa García-Sánchez; Edilio Borroni; Christopher Galli; Esther Pérez-Martínez; Joan Castell-Conesa; Isabel Roca; Lluís Tárraga; Agustín Ruiz; Andrew W. Stephens; Mercè Boada; Gregory Klein; Marta Marquié; on behalf of the FACEHBI study group; on behalf of the AMYPAD consortium |
| Source: |
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-13 (2024) |
| Publisher Information: |
BMC, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Neurosciences. Biological psychiatry. Neuropsychiatry; LCC:Neurology. Diseases of the nervous system |
| Subject Terms: |
Tau; Positron emission tomography; [18F]PI-2620; [18F]RO948; FACEHBI; Subjective cognitive decline; Neurosciences. Biological psychiatry. Neuropsychiatry; RC321-571; Neurology. Diseases of the nervous system; RC346-429 |
| Description: |
Abstract Background Second-generation tau tracers for positron emission tomography (PET) show high affinity for paired helical filaments tau deposits characteristic of Alzheimer´s disease and low off-target binding. Differences in their chemical structure though may lead to variations in their regional tau uptake and off-target signal. In this work, we aimed to compare the in-vivo uptake of tau tracers [18F]PI-2620 and [18F]RO948 in the early stages of the AD continuum. Methods Data from the TAU-PET FACEHBI clinical trial (EUDRA-CT 2021–000473-83) were analyzed. All participants were non-demented and underwent tau imaging with [18F]PI-2620 and [18F]RO948 PET within 3 months, amyloid imaging with [18F]Florbetaben and brain magnetic resonance imaging. Tau PET standardized uptake values ratios (SUVR) were calculated in Braak and typical off-target regions using the inferior cerebellar cortex as a reference region. Results The cohort consisted of 18 individuals with subjective cognitive decline (n = 13) and mild cognitive impairment (n = 5), with centiloid values ranging from 17 to 159. Both tau tracers showed similar tau pathology distribution but presented a distinct off-target signal pattern on visual read. SUVR measurements for [18F]PI-2620 and [18F]RO948 were highly correlated in all Braak regions (R2 range [0.65–0.80]). Regarding off-target signal, [18F]PI-2620 had higher SUVRs in vascular structures, and [18F]RO948 had higher SUVRs in the skull/meninges. Conclusions In a cohort of individuals at early stages of the AD continuum, tau PET tracers [18F]PI-2620 and [18F]RO948 showed similar in-vivo uptake in all Braak regions and distinct off-target signal. These preliminary results support the development of standardized quantification scales for tau deposition that are tracer-independent. Trial registration AEMPS EudraCT 2021–000473-83. Registered 30 December 2021. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1758-9193 |
| Relation: |
https://doaj.org/toc/1758-9193 |
| DOI: |
10.1186/s13195-024-01622-5 |
| Access URL: |
https://doaj.org/article/a701a98f52f341ec8cfdb4e50416d2e5 |
| Accession Number: |
edsdoj.701a98f52f341ec8cfdb4e50416d2e5 |
| Database: |
Directory of Open Access Journals |