| Title: |
Internet-based indicated prevention of anxiety and depression disorder onset three-arm randomized clinical trial |
| Authors: |
Anna-Carlotta Zarski; Kiona K. Weisel; Thomas Berger; Tobias Krieger; Michael P. Schaub; Matthias Berking; Dennis Görlich; Corinna Jacobi; Rosa Baños; Cristina Botella; Rocio Herrero; David D. Ebert |
| Source: |
npj Digital Medicine, Vol 8, Iss 1, Pp 1-7 (2025) |
| Publisher Information: |
Nature Portfolio, 2025. |
| Publication Year: |
2025 |
| Collection: |
LCC:Computer applications to medicine. Medical informatics |
| Subject Terms: |
Computer applications to medicine. Medical informatics; R858-859.7 |
| Description: |
Abstract Preventing mental disorders is important to avoiding clinical conditions. This study evaluated the efficacy of internet-based indicated prevention for anxiety and depressive disorders. In a three-arm randomized controlled trial, 566 adults with subthreshold anxiety (GAD-7 ≥ 5) and/or depressive symptoms (CES-D ≥ 16), but no clinical diagnosis in the past six months (MINI 6.0), were assigned to either an individually (IG-IMI, n = 186) or automatically (AG-IMI, n = 189) guided digital intervention, or waitlist control (WLC, n = 191). The digital intervention comprised 8 transdiagnostic, self-tailored, CBT-based sessions. The primary outcome was time to onset of any anxiety or depressive disorder over 12 months, assessed via blinded diagnostic interviews (MINI). AD/DD onset was 19.4% in IG-IMI, 14.8% in AG-IMI, and 30.9% in WLC. Cumulative incidence was 23.1% (IG-IMI), 20.7% (AG-IMI), and 36.0% (WLC; p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2398-6352 |
| Relation: |
https://doaj.org/toc/2398-6352 |
| DOI: |
10.1038/s41746-025-01990-8 |
| Access URL: |
https://doaj.org/article/7c24e8fbbd064583a7b6a2c7eaeb37d4 |
| Accession Number: |
edsdoj.7c24e8fbbd064583a7b6a2c7eaeb37d4 |
| Database: |
Directory of Open Access Journals |