| Title: |
Ginkgo biloba Extract: A Preliminary Study on Its Radiomitigative Potential Using the Conventional Dicentric Chromosome Assay |
| Authors: |
Julio Cesar Gomes da Silva; CAIO C. V. B. G; MENDES M. E.; LOPES I. M. S. S.; MELO A. M. M. A; LIMA F. F. |
| Source: |
Brazilian Journal of Radiation Sciences, Vol 13, Iss 3A (Suppl.) (2025) |
| Publisher Information: |
Brazilian Radiation Protection Society (Sociedade Brasileira de Proteção Radiológica, SBPR), 2025. |
| Publication Year: |
2025 |
| Collection: |
LCC:Medical physics. Medical radiology. Nuclear medicine; LCC:Radioactivity and radioactive substances |
| Subject Terms: |
Ginkgo biloba; Ionizing radiation; cytogenetic dosimetry; dicentric; Medical physics. Medical radiology. Nuclear medicine; R895-920; Radioactivity and radioactive substances; QC794.95-798 |
| Description: |
Radioprotectors and radiomitigators can be substances of natural or synthetic origin that, once administered to the human body, are capable of preventing, protecting against, or reducing damage caused by radiation. This study aimed to assess the radiomitigating potential of Ginkgo biloba extract by examining the frequency of dicentric chromosomes in irradiated human lymphocytes. Blood samples were obtained from a healthy volunteer. One sample was left in the laboratory as a control, and the others were irradiated in a 60Co source at a dose of 2 Gy and incubated in test concentrations of Ginkgo biloba extract (0.025 and 0.05 μg/ml) according to a standard protocol. Complete metaphases were analyzed, and the frequencies of alterations were statistically evaluated to verify the radiomitigating potential of Ginkgo biloba extract. The ANOVA and Tukey tests revealed a statistically significant difference between the groups treated and untreated with Ginkgo biloba exposed to 2 Gy of radiation (p < 0.05), indicating that both concentrations tested were able to reduce the damage. In this in vitro study, Ginkgo biloba extract was able to reduce the frequency of dicentric chromosomes in irradiated human lymphocytes, with a concentration of 0.025 μg/ml standing out. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2319-0612 |
| Relation: |
https://bjrs.org.br/revista/index.php/REVISTA/article/view/2910; https://doaj.org/toc/2319-0612 |
| DOI: |
10.15392/2319-0612.2025.2910 |
| Access URL: |
https://doaj.org/article/cc7e3d2bbe1146da8ee3bbd1576d5dde |
| Accession Number: |
edsdoj.7e3d2bbe1146da8ee3bbd1576d5dde |
| Database: |
Directory of Open Access Journals |