| Title: |
Brevipedicelones D and E, Two C–O–C Flavonoid Dimmers from the Leaves of Garcinia brevipedicellata and Anti-onchocercal Activity |
| Authors: |
Mirabel Akongwi; Anastasie E. Tih; Kennedy D. Nyongbela; Moses Samje; Raphael T. Ghogomu; Bernard Bodo |
| Source: |
Natural Products and Bioprospecting, Vol 9, Iss 1, Pp 61-68 (2018) |
| Publisher Information: |
SpringerOpen, 2018. |
| Publication Year: |
2018 |
| Collection: |
LCC:Botany |
| Subject Terms: |
Garcinia brevipedicellata; Brevipedicelone; Anti-onchocercal activity; Botany; QK1-989 |
| Description: |
Abstract A novel isoflavone–chromone flavonoid C–O–C dimmer, brevipedicelone D (1), along with one new C–O–C biflavonoid derivative, brevipedicelone E (2), were isolated from the ethyl acetate extract of the leaves of Garcinia brevipedicellata, a medicinal plant used in folk medicine in parts of Cameroon. Their structures were elucidated by extensive spectroscopic techniques, including 1D- and 2D- NMR, MS experiments, as well as comparing their spectral data with those of known analogues. Anti-onchocercal screening of 1 showed moderate inhibition of adult worm motility of Onchocerca ochengi by 60% at the highest concentration (20 µg/mL) and inhibited motility of both the juvenile worms of O. ochengi and Loa loa by 90% at this same concentration. Graphical Abstract |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2192-2195; 2192-2209 |
| Relation: |
http://link.springer.com/article/10.1007/s13659-018-0191-9; https://doaj.org/toc/2192-2195; https://doaj.org/toc/2192-2209 |
| DOI: |
10.1007/s13659-018-0191-9 |
| Access URL: |
https://doaj.org/article/ca7fdc1b15914f00a6957a033a7e0ff9 |
| Accession Number: |
edsdoj.7fdc1b15914f00a6957a033a7e0ff9 |
| Database: |
Directory of Open Access Journals |