| Title: |
Pharmaceutical Cocrystals: New Solid Phase Modification Approaches for the Formulation of APIs |
| Authors: |
Anna Karagianni; Maria Malamatari; Kyriakos Kachrimanis |
| Source: |
Pharmaceutics, Vol 10, Iss 1, p 18 (2018) |
| Publisher Information: |
MDPI AG, 2018. |
| Publication Year: |
2018 |
| Collection: |
LCC:Pharmacy and materia medica |
| Subject Terms: |
cocrystals; coformers; solid state properties; poorly soluble APIs; Pharmacy and materia medica; RS1-441 |
| Description: |
Cocrystals can be used as an alternative approach based on crystal engineering to enhance specific physicochemical and biopharmaceutical properties of active pharmaceutical ingredients (APIs) when the approaches to salt or polymorph formation do not meet the expected targets. In this article, an overview of pharmaceutical cocrystals will be presented, with an emphasis on the intermolecular interactions in cocrystals and the methods for their preparation. Furthermore, cocrystals of direct pharmaceutical interest, along with their in vitro properties and available in vivo data and characterization techniques are discussed, highlighting the potential of cocrystals as an attractive route for drug development. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1999-4923 |
| Relation: |
http://www.mdpi.com/1999-4923/10/1/18; https://doaj.org/toc/1999-4923 |
| DOI: |
10.3390/pharmaceutics10010018 |
| Access URL: |
https://doaj.org/article/8aee6cd0549c4ab3bb8e58fe91ef3e4e |
| Accession Number: |
edsdoj.8aee6cd0549c4ab3bb8e58fe91ef3e4e |
| Database: |
Directory of Open Access Journals |