| Title: |
A study protocol for investigating the sonographic characteristics of neonates with critical illness: an observational cohort study |
| Authors: |
Yan Li; Jingyi Zhang; Xiaolong Zhang; Lin Zhu; Yuan Wang; Xia Chen; Tiantian Xiao; Xiaofeng Zhou; Biao Li; Yiyong Fu; Huaying Li; Linping Zhong; Gaoyang Qin; Xin Zou; Minsheng Zheng; Pinli Zou; Youning Hu; Nana Wu; Shuqiang Gao; Xuhong Hu; Xiaohong Luo; Rong Ju |
| Source: |
BMJ Paediatrics Open, Vol 7, Iss 1 (2023) |
| Publisher Information: |
BMJ Publishing Group, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Pediatrics |
| Subject Terms: |
Pediatrics; RJ1-570 |
| Description: |
Background Haemodynamic instability and hypoxaemia are common and serious threats to the survival of neonates. A growing body of literature indicates that critical care ultrasound has become the optimal evaluation tool for sick neonates. However, few studies have described sonographic characteristics of haemodynamics systematically in the neonates with critical illness. This protocol describes a prospective observational cohort study aimed at (1) characterising the sonographic characteristics of the neonates with critical diseases; and (2) assessing the mortality, significant morbidity, utility of vasoactive medications, fluid resuscitation, duration of ventilation, etc.Methods and analysis This is a single-centre, prospective and observational study conducted in Chengdu Women’s and Children’s Central Hospital from 1 December 2022 to 31 December 2027. Neonates admitted to the neonatal intensive care unit will be recruited. After inclusion, the neonates will undergo the neonatal critical care ultrasound. The data collected via case report forms include clinical variables and sonographic measures. The primary outcome is to identify the sonographic characteristics of sick neonates with different diseases, and the secondary outcome is to describe the mortality, significant morbidity, utility of vasoactive medications, fluid resuscitation and duration of ventilation.Discussion Our study provided an organised neonatal critical care ultrasound workflow, which can be applied in practice. Accordingly, this study will first set up large data on the sonographic description of the neonates with critical illness, which can help to understand the pathophysiology of the critical illness, potentially titrating the treatment.Trial registration number Chinese Clinical Trial Registry (ChiCTR2200065581; https://www.chictr.org.cn/com/25/showproj.aspx?proj=184095). |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2399-9772 |
| Relation: |
https://bmjpaedsopen.bmj.com/content/7/1/e001975.full; https://doaj.org/toc/2399-9772 |
| DOI: |
10.1136/bmjpo-2023-001975 |
| Access URL: |
https://doaj.org/article/9c8bb22425374b4e8a7f4416c6aed445 |
| Accession Number: |
edsdoj.9c8bb22425374b4e8a7f4416c6aed445 |
| Database: |
Directory of Open Access Journals |