| Title: |
Peripartum depression symptom trajectories, telomere length and genotype, and adverse childhood experiences |
| Authors: |
Maria Vrettou; Susanne Lager; Simone Toffoletto; Stavros I. Iliadis; Theodora Kunovac Kallak; Sara Agnafors; Vanessa Nieratschker; Alkistis Skalkidou; Erika Comasco |
| Source: |
BMC Psychiatry, Vol 24, Iss 1, Pp 1-9 (2024) |
| Publisher Information: |
BMC, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Psychiatry |
| Subject Terms: |
Telomere length; Peripartum depression; Adverse childhood experience; TERT; Psychiatry; RC435-571 |
| Description: |
Abstract Background As a biological marker for cellular senescence, telomere length (TL) has been linked to a variety of psychiatric disorders and adverse childhood experiences (ACE), though only preliminarily to peripartum depression (PPD). The present study sought to examine the association between TL and PPD, assessing the moderating role of ACE and genetic polymorphic variations related with the telomere machinery. Methods Adversity was self-reported, likewise were depressive symptoms evaluated at pregnancy week 17 and 32, as well as six-weeks and six-months postpartum. TL was assessed by use of qPCR in blood samples collected during delivery from females with antenatal depression resolving postpartum, females with depression persisting to postpartum, and healthy controls. Twenty haplotype-tagging Single Nucleotide Polymorphisms in the Telomerase Reverse Transcriptase (TERT) and three in the Telomerase RNA Component (TERC) genes were genotyped. Results TL was negatively correlated with severity of PPD symptoms at pregnancy week 32 and postpartum week 6. PPD was associated with shorter TL. Lastly, ACE, but not the TERT/TERC genotype, moderated the TL-trajectory association; with increasing ACE, individuals with persistent PPD symptoms had shorter TL, whereas the opposite pattern (longer TL) was observed in the controls. Conclusions The findings contribute to further understanding of PPD underpinnings, suggesting a negative relationship with TL. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1471-244X |
| Relation: |
https://doaj.org/toc/1471-244X |
| DOI: |
10.1186/s12888-024-06115-1 |
| Access URL: |
https://doaj.org/article/d9de4e49b6b842e9aae605cd842967c2 |
| Accession Number: |
edsdoj.9de4e49b6b842e9aae605cd842967c2 |
| Database: |
Directory of Open Access Journals |