| Title: |
Vitamin C and L-arginine as potential synergistic adjuvants to recover intestinal mucositis induced by chemotherapy |
| Authors: |
Amanda Dias Borges; Raquel Baumgratz Marques; Luiz Octávio Pires; Luísa Martins Trindade; Nayara Salgado Vieira Sette; Maria Emília Rabelo Andrade; Samanta Thomas-Valdés; Paola Caroline Lacerda Leocádio; Jacqueline Isaura Alvarez-Leite; Fernanda Rezende Souza; Geovanni Dantas Cassali; Ramon de Oliveira Souza; Flaviano dos Santos Martins; Valbert Nascimento Cardoso; Simone de Vasconcelos Generoso; Simone Odília Antunes Fernandes |
| Source: |
Clinical Nutrition Open Science, Vol 64, Iss , Pp 377-390 (2025) |
| Publisher Information: |
Elsevier, 2025. |
| Publication Year: |
2025 |
| Collection: |
LCC:Nutrition. Foods and food supply |
| Subject Terms: |
Vitamin C; L-arginine; Immunomodulators; Mucositis; 5-Fluorouracil; Collagen synthesis; Nutrition. Foods and food supply; TX341-641 |
| Description: |
s u m m a r y: Purpose: Chemotherapy-induced intestinal mucositis is a debilitating condition often triggered by 5-fluorouracil (5-FU). This study investigated the effect of vitamin C alone and combined with L-arginine, in a murine model of 5-FU-induced mucositis. Methods: Male BALB/c mice were divided into four groups: Control, Mucositis, Mucositis + Vitamin C, and Mucositis + Vitamin C + Arginine. Treatments were administered by gavage for 10 days, with mucositis induction on day 7. Clinical (body weight, food intake), histological, morphometric, immunological, oxidative stress, and gene expression parameters were evaluated. Results: Mucositis significantly reduced weight and food intake (P |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2667-2685 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2667268525001184; https://doaj.org/toc/2667-2685 |
| DOI: |
10.1016/j.nutos.2025.10.013 |
| Access URL: |
https://doaj.org/article/b1cef6418dfd4f96bc46509a904dd25e |
| Accession Number: |
edsdoj.b1cef6418dfd4f96bc46509a904dd25e |
| Database: |
Directory of Open Access Journals |