Serum Neurofilament Light Chain in Multiple Sclerosis: Superiority of Age‐ and BMI‐Corrected Z Scores/Percentiles Over Absolute Cutoff Values for Prediction of Treatment Response
| Title: | Serum Neurofilament Light Chain in Multiple Sclerosis: Superiority of Age‐ and BMI‐Corrected Z Scores/Percentiles Over Absolute Cutoff Values for Prediction of Treatment Response |
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| Authors: | Maximilian Einsiedler; Aleksandra Maleska Maceski; Sofia Sandgren; Johanna Oechtering; Sabine Schaedelin; Lisa Hofer; Amar Zadic; Juan Francisco Vilchez Gomez; Lester Melie‐Garcia; Alessandro Cagol; Riccardo Galbusera; Sebastian Finkener; Patrice Lalive; Marjolaine Uginet; Stefanie Müller; Caroline Pot; Amandine Mathias; Renaud Du Pasquier; Robert Hoepner; Andrew Chan; Giulio Disanto; Chiara Zecca; Marcus D’Souza; Lars G. Hemkens; Tobias Derfuss; Özgür Yaldizli; Patrick Roth; Claudio Gobbi; David Brassat; Björn Tackenberg; Henrik Zetterberg; Tjalf Ziemssen; Heinz Wiendl; Klaus Berger; Marco Hermesdorf; Fredrik Piehl; Ludwig Kappos; Cristina Granziera; Ahmed Abdelhak; David Leppert; Eline A. J. Willemse; Pascal Benkert; Jens Kuhle; Swiss Multiple Sclerosis Cohort Study (SMSC) |
| Source: | Annals of Clinical and Translational Neurology, Vol 12, Iss 11, Pp 2214-2225 (2025) |
| Publisher Information: | Wiley, 2025. |
| Publication Year: | 2025 |
| Collection: | LCC:Neurosciences. Biological psychiatry. Neuropsychiatry; LCC:Neurology. Diseases of the nervous system |
| Subject Terms: | multiple sclerosis; neurofilament; prediction; Z scores; Neurosciences. Biological psychiatry. Neuropsychiatry; RC321-571; Neurology. Diseases of the nervous system; RC346-429 |
| Description: | ABSTRACT Objective Prognostication of disease course and prediction of treatment response in multiple sclerosis is an unmet need. We compared the performance of serum neurofilament light chain Z scores (age‐ and BMI‐adjusted) with absolute concentrations for the prediction of response to disease‐modifying therapy. Methods Observational cohort study including the first serum sample of participants after the start of fingolimod therapy. We estimated hazard ratios for future relapses comparing participants with high (upper quartile) versus lower neurofilament light chain levels, based on either absolute concentration or Z score cutoffs. We compared the prognostic/predictive performance of these two measures for the occurrence of new/enlarging T2w lesions in longitudinal MRI. Results We included 447 participants (median [IQR] age, 41.3 [32.1–49.2] years; 65.1% female); median follow‐up 8.3 years [6.0–10.3]. Participants with a high neurofilament light chain Z score (Z ≥ 1.2/88.5 percentile) were more likely to experience future relapses (HR: 1.80, 95% CI 1.27–2.54, p |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2328-9503 |
| Relation: | https://doaj.org/toc/2328-9503 |
| DOI: | 10.1002/acn3.70149 |
| Access URL: | https://doaj.org/article/b3155ca67b514b54b65b64d008489d58 |
| Accession Number: | edsdoj.b3155ca67b514b54b65b64d008489d58 |
| Database: | Directory of Open Access Journals |