16p11.2 deletion is associated with hyperactivation of human iPSC-derived dopaminergic neuron networks and is rescued by RHOA inhibition in vitro
| Title: | 16p11.2 deletion is associated with hyperactivation of human iPSC-derived dopaminergic neuron networks and is rescued by RHOA inhibition in vitro |
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| Authors: | Maria Sundberg; Hannah Pinson; Richard S. Smith; Kellen D. Winden; Pooja Venugopal; Derek J. C. Tai; James F. Gusella; Michael E. Talkowski; Christopher A. Walsh; Max Tegmark; Mustafa Sahin |
| Source: | Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021) |
| Publisher Information: | Nature Portfolio, 2021. |
| Publication Year: | 2021 |
| Collection: | LCC:Science |
| Subject Terms: | Science |
| Description: | 16p11.2 CNVs are associated with neurodevelopmental disorders. Here, the authors show that 16p11.2 deletion is associated with hyperactivation of human iPSC-derived dopaminergic neuron networks and is rescued by RHOA inhibition in vitro. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2041-1723 |
| Relation: | https://doaj.org/toc/2041-1723 |
| DOI: | 10.1038/s41467-021-23113-z |
| Access URL: | https://doaj.org/article/b6ffb9fd39d845a3b76fce24f582a800 |
| Accession Number: | edsdoj.b6ffb9fd39d845a3b76fce24f582a800 |
| Database: | Directory of Open Access Journals |