A clinical transcriptome approach to patient stratification and therapy selection in acute myeloid leukemia
| Title: | A clinical transcriptome approach to patient stratification and therapy selection in acute myeloid leukemia |
|---|---|
| Authors: | T. Roderick Docking; Jeremy D. K. Parker; Martin Jädersten; Gerben Duns; Linda Chang; Jihong Jiang; Jessica A. Pilsworth; Lucas A. Swanson; Simon K. Chan; Readman Chiu; Ka Ming Nip; Samantha Mar; Angela Mo; Xuan Wang; Sergio Martinez-Høyer; Ryan J. Stubbins; Karen L. Mungall; Andrew J. Mungall; Richard A. Moore; Steven J. M. Jones; İnanç Birol; Marco A. Marra; Donna Hogge; Aly Karsan |
| Source: | Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021) |
| Publisher Information: | Nature Portfolio, 2021. |
| Publication Year: | 2021 |
| Collection: | LCC:Science |
| Subject Terms: | Science |
| Description: | Several genomic features have been found for acute myeloid leukaemia (AML) but targeted clinical genetic testing fails to predict prognosis. Here, the authors generate an AML prognostic score from RNA-seq data of patients, which successfully stratifies AML patients and which may provide guidance for therapeutic strategies. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2041-1723 |
| Relation: | https://doaj.org/toc/2041-1723 |
| DOI: | 10.1038/s41467-021-22625-y |
| Access URL: | https://doaj.org/article/b8f2ebaeb4ca47dbbfddf2abb90ffb18 |
| Accession Number: | edsdoj.b8f2ebaeb4ca47dbbfddf2abb90ffb18 |
| Database: | Directory of Open Access Journals |