| Title: |
The Impact of Periodontal Therapy on Systemic Inflammatory Markers and Cardiovascular Disease Risk in Patients with Chronic Periodontitis |
| Authors: |
Deepti Shrivastava; Abdullah R. F. Alanazi; Zayed M. A. Altimani; Abdullah M. Alsalem; Mohammad K. Alam; Kumar C. Srivastava |
| Source: |
Journal of Pharmacy and Bioallied Sciences, Vol 16, Iss Suppl 4, Pp S3901-S3903 (2024) |
| Publisher Information: |
Wolters Kluwer Medknow Publications, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Pharmacy and materia medica; LCC:Analytical chemistry |
| Subject Terms: |
cardiovascular disease; chronic periodontitis; c-reactive protein; framingham risk score; interleukin-6; periodontal therapy; systemic inflammatory markers; tumor necrosis factor-alpha; Pharmacy and materia medica; RS1-441; Analytical chemistry; QD71-142 |
| Description: |
Background: A common inflammatory condition that damages the tissues that support teeth, chronic periodontitis has become more closely associated with systemic health conditions, especially cardiovascular disease (CVD). Materials and Methods: In this randomized controlled experiment, 100 individuals with a diagnosis of chronic periodontitis were included. Two groups of participants were created: a treatment group (n = 50) that received scaling and root planning as well as other non-surgical periodontal care, and a control group (n = 50) that did not receive any treatment. Measurements were taken at baseline and 6 months after therapy for systemic inflammatory markers, including as C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α). The Framingham Risk Score (FRS) was used at the same intervals to evaluate the risk of CVD. Results: At 6 months after therapy, patients in the treatment group had substantial reductions in all measured inflammatory markers: CRP was down 30% (P < 0.01), IL-6 was down 25% (P < 0.05), and TNF-α was down 28% (P < 0.01). In the therapy group, the Framingham Risk Score dropped by 15% (P < 0.05), suggesting a lower chance of cardiovascular disease. There were no noteworthy alterations noted in the group under control. Conclusion: In individuals with persistent periodontitis, non-surgical periodontal treatment may minimize the risk of cardiovascular disease and considerably reduce systemic inflammatory indicators. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
0976-4879; 0975-7406 |
| Relation: |
https://journals.lww.com/10.4103/jpbs.jpbs_1216_24; https://doaj.org/toc/0976-4879; https://doaj.org/toc/0975-7406 |
| DOI: |
10.4103/jpbs.jpbs_1216_24 |
| Access URL: |
https://doaj.org/article/df072916b2af46efbb41e2efdc7a424e |
| Accession Number: |
edsdoj.f072916b2af46efbb41e2efdc7a424e |
| Database: |
Directory of Open Access Journals |