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Semantic search helper: A tool based on the use of embeddings in multi-item questionnaires as a harmonization opportunity for merging large datasets – A feasibility study

Title: Semantic search helper: A tool based on the use of embeddings in multi-item questionnaires as a harmonization opportunity for merging large datasets – A feasibility study
Authors: Karl Gottfried; Karina Janson; Nathalie E. Holz; Olaf Reis; Johannes Kornhuber; Anna Eichler; Tobias Banaschewski; Frauke Nees; IMAC-Mind Consortium
Source: European Psychiatry, Vol 68 (2025)
Publisher Information: Cambridge University Press, 2025.
Publication Year: 2025
Collection: LCC:Psychiatry
Subject Terms: natural language processing; harmonization; semantic; questionnaires; big data; Psychiatry; RC435-571
Description: Abstract Background Recent advances in natural language processing (NLP), particularly in language processing methods, have opened new avenues in semantic data analysis. A promising application of NLP is data harmonization in questionnaire-based cohort studies, where it can be used as an additional method, specifically when only different instruments are available for one construct as well as for the evaluation of potentially new construct-constellations. The present article therefore explores embedding models’ potential to detect opportunities for semantic harmonization. Methods Using models like SBERT and OpenAI’s ADA, we developed a prototype application (“Semantic Search Helper”) to facilitate the harmonization process of detecting semantically similar items within extensive health-related datasets. The approach’s feasibility and applicability were evaluated through a use case analysis involving data from four large cohort studies with heterogeneous data obtained with a different set of instruments for common constructs. Results With the prototype, we effectively identified potential harmonization pairs, which significantly reduced manual evaluation efforts. Expert ratings of semantic similarity candidates showed high agreement with model-generated pairs, confirming the validity of our approach. Conclusions This study demonstrates the potential of embeddings in matching semantic similarity as a promising add-on tool to assist harmonization processes of multiplex data sets and instruments but with similar content, within and across studies.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 0924-9338; 1778-3585
Relation: https://www.cambridge.org/core/product/identifier/S092493382401808X/type/journal_article; https://doaj.org/toc/0924-9338; https://doaj.org/toc/1778-3585
DOI: 10.1192/j.eurpsy.2024.1808
Access URL: https://doaj.org/article/f5fc7e1f2ad24fc7bfc9a9be77ea4be8
Accession Number: edsdoj.f5fc7e1f2ad24fc7bfc9a9be77ea4be8
Database: Directory of Open Access Journals