| Title: |
High Plasma Levels of Soluble Lectin‐like Oxidized Low‐Density Lipoprotein Receptor‐1 Are Associated With Inflammation and Cardiometabolic Risk Profiles in Pediatric Overweight and Obesity |
| Authors: |
Sara E. Stinson; Anna E. Jonsson; Mette K. Andersen; Morten A. V. Lund; Louise Aas Holm; Cilius E. Fonvig; Yun Huang; Evelina Stankevič; Helene Bæk Juel; Lars Ängquist; Thorkild I. A. Sørensen; Emily L. Ongstad; Ranjitha Gaddipati; Joseph Grimsby; Christopher J. Rhodes; Oluf Pedersen; Michael Christiansen; Jens‐Christian Holm; Torben Hansen |
| Source: |
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 3 (2023) |
| Publisher Information: |
Wiley, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Diseases of the circulatory (Cardiovascular) system |
| Subject Terms: |
adolescent; child; obesity; overweight; soluble lectin‐like oxidized low‐density lipoprotein receptor‐1; Diseases of the circulatory (Cardiovascular) system; RC666-701 |
| Description: |
Background Lectin‐like oxidized low‐density lipoprotein (ox‐LDL) receptor‐1 is a scavenger receptor for oxidized low‐density lipoprotein. In adults, higher soluble lectin‐like ox‐LDL receptor‐1 (sLOX‐1) levels are associated with cardiovascular disease, type 2 diabetes, and obesity, but a similar link in pediatric overweight/obesity remains uncertain. Methods and Results Analyses were based on the cross‐sectional HOLBAEK Study, including 4‐ to 19‐year‐olds from an obesity clinic group with body mass index >90th percentile (n=1815) and from a population‐based group (n=2039). Fasting plasma levels of sLOX‐1 and inflammatory markers were quantified, cardiometabolic risk profiles were assessed, and linear and logistic regression analyses were performed. Pubertal/postpubertal children and adolescents from the obesity clinic group exhibited higher sLOX‐1 levels compared with the population (P |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2047-9980 |
| Relation: |
https://doaj.org/toc/2047-9980 |
| DOI: |
10.1161/JAHA.122.027042 |
| Access URL: |
https://doaj.org/article/f8e2b7bde0c84cd1a9abf38ec9a67ea9 |
| Accession Number: |
edsdoj.f8e2b7bde0c84cd1a9abf38ec9a67ea9 |
| Database: |
Directory of Open Access Journals |