| Title: |
Comparative infection risk in CAR T vs bispecific antibodies in B-cell lymphoma: a systematic review and meta-analysis |
| Authors: |
Herman van Besien; Neela Easwar; Michelle Demetres; Michelle Pasciolla; Tsiporah Shore; John Leonard; Juliet Barker; Peter Martin; Samuel Yamshon |
| Source: |
Blood Advances, Vol 9, Iss 23, Pp 6063-6075 (2025) |
| Publisher Information: |
Elsevier, 2025. |
| Publication Year: |
2025 |
| Collection: |
LCC:Specialties of internal medicine |
| Subject Terms: |
Specialties of internal medicine; RC581-951 |
| Description: |
Abstract: CD3xCD20 bispecific antibody (BsAb) therapy and CD19-directed chimeric antigen receptor T-cell therapy (CAR T) are novel immunotherapies that have shown impressive efficacy in B-cell lymphomas, but also come with significant morbidity and mortality, including infections. This meta-analysis compares rates of infections between commercially approved CAR T and BsAb therapy in patients with B-cell non-Hodgkin lymphoma (B-NHL). We conducted a systematic review for prospective trials assessing commercially approved CAR T and BsAbs in patients with B-NHL. Twenty-five studies comprising 3202 patients were included in the analysis. We used random effects models to evaluate all-grade infections, grade 3+ infections, and infection-related mortality, calculating both pooled rates per patient and per patient-month. While CAR T and BsAbs had similar rates of all-grade infections per patient (0.44 vs 0.54; P = .18), BsAbs had a higher rate of infection per patient-month (0.0397 vs 0.0167; P = .0012). Similarly, CAR T and BsAbs had similar rates of grade 3+ infections per patient (0.16 vs 0.22; P = .08), while BsAbs had a higher rate of grade 3+ infections per patient-month (0.0165 vs 0.0069; P = .0003). CAR T and BsAb products had similar rates of infection-related mortality per patient (0.04 vs 0.03; P = .26) and per patient-month (0.0023 vs 0.0022; P = .96). Our findings point to the potential increased burden of infections over time in patients receiving BsAb therapy, particularly for patients on indefinite therapy. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2473-9529 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S247395292500374X; https://doaj.org/toc/2473-9529 |
| DOI: |
10.1182/bloodadvances.2025016291 |
| Access URL: |
https://doaj.org/article/afcdf314f8764bb3bc02eda99c8a4d81 |
| Accession Number: |
edsdoj.fcdf314f8764bb3bc02eda99c8a4d81 |
| Database: |
Directory of Open Access Journals |