| Title: |
An update on nuclear calcium signalling |
| Authors: |
Bootman, Martin D.; Fearnley, Claire; Smyrnias, Ioannis; MacDonald, Fraser; Roderick, H. Llewelyn |
| Document Type: |
Electronic Resource |
| Abstract: |
Over the past 15 years or so, numerous studies have sought to characterise how nuclear calcium (Ca2+) signals are generated and reversed, and to understand how events that occur in the nucleoplasm influence cellular Ca2+ activity, and vice versa. In this Commentary, we describe mechanisms of nuclear Ca2+ signalling and discuss what is known about the origin and physiological significance of nuclear Ca2+ transients. In particular, we focus on the idea that the nucleus has an autonomous Ca2+ signalling system that can generate its own Ca2+ transients that modulate processes such as gene transcription. We also discuss the role of nuclear pores and the nuclear envelope in controlling ion flux into the nucleoplasm. |
| Index Terms: |
Journal Item; Public; PeerReviewed |
| URL: |
http://oro.open.ac.uk/34861/1/bootman_nuclear%20review_%282009%29.pdf; http://oro.open.ac.uk/34861/; http://dx.doi.org/10.1242/jcs.028100; http://oro.open.ac.uk/34861 |
| Availability: |
Open access content. Open access content |
| Note: |
application/pdf; Bootman, Martin D. ; Fearnley, Claire; Smyrnias, Ioannis; MacDonald, Fraser and Roderick, H. Llewelyn (2009). An update on nuclear calcium signalling. Journal of Cell Science, 122 pp. 2337–2350. |
| Other Numbers: |
HS0 oai:oro.open.ac.uk:34861; Bootman, Martin D. ; Fearnley, Claire; Smyrnias, Ioannis; MacDonald, Fraser and Roderick, H. Llewelyn (2009). An update on nuclear calcium signalling. Journal of Cell Science, 122 pp. 2337–2350.; 1031216919 |
| Contributing Source: |
OPEN UNIV, THE; From OAIster®, provided by the OCLC Cooperative. |
| Accession Number: |
edsoai.on1031216919 |
| Database: |
OAIster |