| Title: |
Diagnostic Accuracy of the Spectralis and Cirrus Reference Databases in Differentiating between Healthy and Early Glaucoma Eyes. |
| Authors: |
Silverman, Anna L; Silverman, Anna L; Hammel, Naama; Khachatryan, Naira; Sharpsten, Lucie; Medeiros, Felipe A; Girkin, Christopher A; Liebmann, Jeffrey M; Weinreb, Robert N; Zangwill, Linda M |
| Source: |
Ophthalmology; vol 123, iss 2, 408-414; 0161-6420 |
| Publisher Information: |
eScholarship, University of California 2016-02-01 |
| Document Type: |
Electronic Resource |
| Abstract: |
PurposeTo evaluate and compare the diagnostic accuracy of global and sector analyses for detection of early visual field (VF) damage using the retinal nerve fiber layer (RNFL) reference databases of the Spectralis (Heidelberg Engineering, Heidelberg, Germany) and Cirrus (Carl Zeiss Meditec, Dublin, CA) spectral-domain optical coherence tomography (SD OCT) devices.MethodsHealthy subjects and glaucoma suspects from the Diagnostic Innovations in Glaucoma Study (DIGS) and African Descent and Glaucoma Evaluation Study (ADAGES) with at least 2 years of follow-up were included. Global and sectoral RNFL measures were classified as within normal limits, borderline (BL), and outside normal limits (ONL) on the basis of the device reference databases. The sensitivity of ONL classification was estimated in glaucoma suspect eyes that developed repeatable VF damage.ResultsA total of 353 glaucoma suspect eyes and 279 healthy eyes were included. A total of 34 (9.6%) of the glaucoma suspect eyes developed VF damage. In glaucoma suspect eyes, Spectralis and Cirrus ONL classification was present in 47 eyes (13.3%) and 24 eyes (6.8%), respectively. The sensitivity of the global RNFL ONL classification among eyes that developed VF damage was 23.5% for Cirrus and 32.4% for Spectralis. The specificity of within-normal-limits global classification in healthy eyes was 100% for Cirrus and 99.6% for Spectralis. There was moderate to substantial agreement between Cirrus and Spectralis classification as ONL.ConclusionsThe Spectralis and Cirrus reference databases have a high specificity for identifying healthy eyes and good agreement for detection of eyes with early glaucoma damage. |
| Index Terms: |
Nerve Fibers; Retinal Ganglion Cells; Humans; Vision Disorders; Ocular Hypertension; Tomography; Optical Coherence; Gonioscopy; Early Diagnosis; Sensitivity and Specificity; Reproducibility of Results; Visual Fields; Databases; Factual; Aged; Middle Aged; African Americans; Visual Field Tests; Healthy Volunteers; Clinical Research; Eye Disease and Disorders of Vision; Neurodegenerative; Aging; Neurosciences; 4.2 Evaluation of markers and technologies; Eye; Ophthalmology & Optometry; Clinical Sciences; Opthalmology and Optometry; Public Health and Health Services; article |
| URL: |
https://escholarship.org/uc/item/9pp9x3b1; https://escholarship.org/ |
| Availability: |
Open access content. Open access content; public |
| Note: |
Ophthalmology vol 123, iss 2, 408-414 0161-6420 |
| Other Numbers: |
CDLER oai:escholarship.org:ark:/13030/qt9pp9x3b1; qt9pp9x3b1; https://escholarship.org/uc/item/9pp9x3b1; https://escholarship.org/; 1287360686 |
| Contributing Source: |
UC MASS DIGITIZATION; From OAIster®, provided by the OCLC Cooperative. |
| Accession Number: |
edsoai.on1287360686 |
| Database: |
OAIster |