| Title: |
International electronic health record-derived COVID-19 clinical course profiles: the 4CE consortium. |
| Authors: |
Brat, Gabriel A; Brat, Gabriel A; Weber, Griffin M; Gehlenborg, Nils; Avillach, Paul; Palmer, Nathan P; Chiovato, Luca; Cimino, James; Waitman, Lemuel R; Omenn, Gilbert S; Malovini, Alberto; Moore, Jason H; Beaulieu-Jones, Brett K; Tibollo, Valentina; Murphy, Shawn N; Yi, Sehi L'; Keller, Mark S; Bellazzi, Riccardo; Hanauer, David A; Serret-Larmande, Arnaud; Gutierrez-Sacristan, Alba; Holmes, John J; Bell, Douglas S; Mandl, Kenneth D; Follett, Robert W; Klann, Jeffrey G; Murad, Douglas A; Scudeller, Luigia; Bucalo, Mauro; Kirchoff, Katie; Craig, Jean; Obeid, Jihad; Jouhet, Vianney; Griffier, Romain; Cossin, Sebastien; Moal, Bertrand; Patel, Lav P; Bellasi, Antonio; Prokosch, Hans U; Kraska, Detlef; Sliz, Piotr; Tan, Amelia LM; Ngiam, Kee Yuan; Zambelli, Alberto; Mowery, Danielle L; Schiver, Emily; Devkota, Batsal; Bradford, Robert L; Daniar, Mohamad; Daniel, Christel; Benoit, Vincent; Bey, Romain; Paris, Nicolas; Serre, Patricia; Orlova, Nina; Dubiel, Julien; Hilka, Martin; Jannot, Anne Sophie; Breant, Stephane; Leblanc, Judith; Griffon, Nicolas; Burgun, Anita; Bernaux, Melodie; Sandrin, Arnaud; Salamanca, Elisa; Cormont, Sylvie; Ganslandt, Thomas; Gradinger, Tobias; Champ, Julien; Boeker, Martin; Martel, Patricia; Esteve, Loic; Gramfort, Alexandre; Grisel, Olivier; Leprovost, Damien; Moreau, Thomas; Varoquaux, Gael; Vie, Jill-Jênn; Wassermann, Demian; Mensch, Arthur; Caucheteux, Charlotte; Haverkamp, Christian; Lemaitre, Guillaume; Bosari, Silvano; Krantz, Ian D; South, Andrew; Cai, Tianxi; Kohane, Isaac S |
| Source: |
NPJ digital medicine; vol 3, iss 1, 109; 2398-6352 |
| Publisher Information: |
eScholarship, University of California 2020-01-01 |
| Document Type: |
Electronic Resource |
| Abstract: |
We leveraged the largely untapped resource of electronic health record data to address critical clinical and epidemiological questions about Coronavirus Disease 2019 (COVID-19). To do this, we formed an international consortium (4CE) of 96 hospitals across five countries (www.covidclinical.net). Contributors utilized the Informatics for Integrating Biology and the Bedside (i2b2) or Observational Medical Outcomes Partnership (OMOP) platforms to map to a common data model. The group focused on temporal changes in key laboratory test values. Harmonized data were analyzed locally and converted to a shared aggregate form for rapid analysis and visualization of regional differences and global commonalities. Data covered 27,584 COVID-19 cases with 187,802 laboratory tests. Case counts and laboratory trajectories were concordant with existing literature. Laboratory tests at the time of diagnosis showed hospital-level differences equivalent to country-level variation across the consortium partners. Despite the limitations of decentralized data generation, we established a framework to capture the trajectory of COVID-19 disease in patients and their response to interventions. |
| Index Terms: |
Databases; Outcomes research; Viral infection; article |
| URL: |
https://escholarship.org/uc/item/83c7s54k; https://escholarship.org/ |
| Availability: |
Open access content. Open access content; public |
| Note: |
application/pdf; NPJ digital medicine vol 3, iss 1, 109 2398-6352 |
| Other Numbers: |
CDLER oai:escholarship.org:ark:/13030/qt83c7s54k; qt83c7s54k; https://escholarship.org/uc/item/83c7s54k; https://escholarship.org/; 1287375294 |
| Contributing Source: |
UC MASS DIGITIZATION; From OAIster®, provided by the OCLC Cooperative. |
| Accession Number: |
edsoai.on1287375294 |
| Database: |
OAIster |