| Title: |
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture |
| Authors: |
Berndt, S; Gustafsson, S; Mägi, R; Ganna, A; Wheeler, E; Feitosa, M; Justice, A; Monda, K; Croteau Chonka, D; Day, F; Esko, T; Fall, T; Ferreira, T; Gentilini, D; Jackson, A; Luan, J; Randall, J; Vedantam, S; Willer, C; Winkler, T; Wood, A; Workalemahu, T; Hu, Y; Lee, S; Liang, L; Lin, D; Min, J; Neale, B; Thorleifsson, G; Yang, J; Albrecht, E; Amin, N; Bragg Gresham, J; Cadby, G; den Heijer, M; Eklund, N; Fischer, K; Goel, A; Hottenga, J; Huffman, J; Jarick, I; Johansson, Å; Johnson, T; Kanoni, S; Kleber, M; König, I; Kristiansson, K; Kutalik, Z; Lamina, C; Lecoeur, C; Li, G; Mangino, M; Mcardle, W; Medina Gomez, C; Müller Nurasyid, M; Ngwa, J; Nolte, I; Paternoster, L; Pechlivanis, S; Perola, M; Peters, M; Preuss, M; Rose, L; Shi, J; Shungin, D; Smith, A; Strawbridge, R; Surakka, I; Teumer, A; Trip, M; Tyrer, J; Van Vliet Ostaptchouk, J; Vandenput, L; Waite, L; Zhao, J; Absher, D; Asselbergs, F; Atalay, M; Attwood, A; Balmforth, A; Basart, H; Beilby, J; Bonnycastle, L; Brambilla, P; Bruinenberg, M; Campbell, H; Chasman, D; Chines, P; Collins, F; Connell, J; Cookson, W; De, F; U, D; Vegt, F; Dei, M; Dimitriou, M; Edkins, S; Estrada, K; Evans, D; Farrall, M; Ferrario, M; Ferrières, J; Franke, L; Frau, F; Gejman, P; Grallert, H; Grönberg, H; Gudnason, V; Hall, A; Hall, P; Hartikainen, A; Hayward, C; Heard Costa, N; Heath, A; Hebebrand, J; Homuth, G; Hu, F; Hunt, S; Hyppönen, E; Iribarren, C; Jacobs, K; Jansson, J; Jula, A; Kähönen, M; Kathiresan, S; Kee, F; Khaw, K; Kivimäki, M; Koenig, W; Kraja, A; Kumari, M; Kuulasmaa, K; Kuusisto, J; Laitinen, J; Lakka, T; Langenberg, C; Launer, L; Lind, L; Lindström, J; Liu, J; Liuzzi, A; Lokki, M; Lorentzon, M; Madden, P; Magnusson, P; Manunta, P; Marek, D; März, W; Mateo Leach, I; Mcknight, B; Medland, S; Mihailov, E; Milani, L; Montgomery, G; Mooser, V; Mühleisen, T; Munroe, P; Musk, A; Narisu, N; Navis, G; Nicholson, G; Nohr, E; Ong, K; Oostra, B; Palmer, C; Palotie, A; Peden, J; Pedersen, N; Peters, A; Polasek, O; Pouta, A; Pramstaller, P; Prokopenko, I; Pütter, C; Radhakrishnan, A; Raitakari, O; Rendon, A; Rivadeneira, F; Rudan, I; Saaristo, T; Sambrook, J; Sanders, A; Sanna, S; Saramies, J; Schipf, S; Schreiber, S; Schunkert, H; Shin, S; Signorini, S; Sinisalo, J; Skrobek, B; Soranzo, N; Stančáková, A; Stark, K; Stephens, J; Stirrups, K; Stolk, R; Stumvoll, M; Swift, A; Theodoraki, E; Thorand, B; Tregouet, D; Tremoli, E; Van der Klauw, M; van Meurs, J; Vermeulen, S; Viikari, J; Virtamo, J; Vitart, V; Waeber, G; Wang, Z; Widén, E; Wild, S; Willemsen, G; Winkelmann, B; Witteman, J; Wolffenbuttel, B; Wong, A; Wright, A; Zillikens, M; Amouyel, P; Boehm, B; Boerwinkle, E; Boomsma, D; Caulfield, M; Chanock, S; Cupples, L; Cusi, D; Dedoussis, G; Erdmann, J; Eriksson, J; Franks, P; Froguel, P; Gieger, C; Gyllensten, U; Hamsten, A; Harris, T; Hengstenberg, C; Hicks, A; Hingorani, A; Hinney, A; Hofman, A; Hovingh, K; Hveem, K; Illig, T; Jarvelin, M; Jöckel, K; Keinanen Kiukaanniemi, S; Kiemeney, L; Kuh, D; Laakso, M; Lehtimäki, T; Levinson, D; Martin, N; Metspalu, A; Morris, A; Nieminen, M; Njølstad, I; Ohlsson, C; Oldehinkel, A; Ouwehand, W; Palmer, L; Penninx, B; Power, C; Province, M; Psaty, B; Qi, L; Rauramaa, R; Ridker, P; Ripatti, S; Salomaa, V; Samani, N; Snieder, H; Sørensen, T; Spector, T; Stefansson, K; Tönjes, A; Tuomilehto, J; Uitterlinden, A; Uusitupa, M; van der Harst, P; Vollenweider, P; Wallaschofski, H; Wareham, N; Watkins, H; Wichmann, H; Wilson, J; Abecasis, G; Assimes, T; Barroso, I; Boehnke, M; Borecki, I; Deloukas, P; Fox, C; Frayling, T; Groop, L; Haritunian, T; Heid, I; Hunter, D; Kaplan, R; Karpe, F; Moffatt, M; Mohlke, K; O'Connell, J; Pawitan, Y; Schadt, E; Schlessinger, D; Steinthorsdottir, V; Strachan, D; Thorsteinsdottir, U; Van, D; Cm; Visscher, P; Di Blasio, A; Hirschhorn, J; Lindgren, C; Meyre, D; Scherag, A; Mccarthy, M; Speliotes, E; North, K; Loos, R; Ingelsson, E; Berndt, SI; Feitosa, MF; Justice, AE; Monda, KL; Croteau Chonka, DC; Day, FR; Jackson, AU; Randall, JC; Willer, CJ; Winkler, TW; Wood, AR; Hu, YJ; Lee, SH; Lin, DY; Min, JL; Neale, BM; Bragg Gresham, JL; Hottenga, JJ; Huffman, JE; Kleber, ME; König, IR; McArdle, WL; Ngwa, JS; Nolte, IM; Peters, MJ; Rose, LM; Smith, AV; Strawbridge, RJ; Trip, MD; Van Vliet Ostaptchouk, JV; Waite, LL; Zhao, JH; Asselbergs, FW; Attwood, AP; Balmforth, AJ; Bonnycastle, LL; Chasman, DI; Chines, PS; Collins, FS; Connell, JM; Cookson, WO; de, Faire; U, de; Evans, DM; Ferrario, MM; Gejman, PV; Hall, AS; Hartikainen, AL; Heard Costa, NL; Heath, AC; Hu, FB; Hunt, SE; Jacobs, KB; Jansson, JO; Khaw, KT; Kraja, AT; Laitinen, JH; Lakka, TA; Launer, LJ; Lokki, ML; Madden, PA; Magnusson, PK; McKnight, B; Medland, SE; Montgomery, GW; Mühleisen, TW; Munroe, PB; Musk, AW; Nohr, EA; Ong, KK; Oostra, BA; Palmer, CN; Peden, JF; Pramstaller, PP; Saaristo, TE; Sambrook, JG; Sanders, AR; Shin, SY; Stephens, JC; Stolk, RP; Swift, AJ; Theodoraki, EV; Tregouet, DA; Van der Klauw, MM; van Meurs, JB; Vermeulen, SH; Wild, SH; Winkelmann, BR; Witteman, JC; Wolffenbuttel, BH; Wright, AF; Zillikens, MC; Boehm, BO; Boomsma, DI; Caulfield, MJ; Chanock, SJ; Cupples, LA; Dedoussis, GV; Eriksson, JG; Franks, PW; Harris, TB; Hicks, AA; Hovingh, KG; Jarvelin, MR; Jöckel, KH; Keinanen Kiukaanniemi, SM; Kiemeney, LA; Levinson, DF; Martin, NG; Morris, AD; Nieminen, MS; Oldehinkel, AJ; Ouwehand, WH; Palmer, LJ; Province, MA; Psaty, BM; Ridker, PM; Samani, NJ; Sørensen, TI; Spector, TD; Uitterlinden, AG; Wareham, NJ; Wichmann, HE; Wilson, JF; Abecasis, GR; Assimes, TL; Borecki, IB; Fox, CS; Groop, LC; Heid, IM; Kaplan, RC; Moffatt, MF; Mohlke, KL; O'Connell, JR; Schadt, EE; Strachan, DP; van, Duijn; CM; Visscher, PM; Di Blasio, AM; Hirschhorn, JN; Lindgren, CM; Morris, AP; McCarthy, MI; Speliotes, EK; North, KE; Loos, RJ; Ingelsson, E.; BRAMBILLA, PAOLO |
| Publisher Information: |
Nature America, Inc. country:GB 2013 |
| Document Type: |
Electronic Resource |
| Abstract: |
Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity. Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups |
| Index Terms: |
BMI, height, WHR, obesity, GWS; Settore BIOS-09/A - Biochimica clinica e biologia molecolare clinica; info:eu-repo/semantics/article |
| URL: |
http://hdl.handle.net/10281/45707; info:eu-repo/semantics/altIdentifier/pmid/23563607; info:eu-repo/semantics/altIdentifier/wos/WOS:000318158200011; volume:45; issue:5; firstpage:501; lastpage:512; numberofpages:12; journal:NATURE GENETICS |
| Availability: |
Open access content. Open access content |
| Note: |
STAMPA; English |
| Other Numbers: |
ITBAO oai:boa.unimib.it:10281/45707; 10.1038/ng.2606; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84878594902; 1308905298 |
| Contributing Source: |
BICOCCA OPEN ARCH; From OAIster®, provided by the OCLC Cooperative. |
| Accession Number: |
edsoai.on1308905298 |
| Database: |
OAIster |