| Title: |
Evaluating the Sum of Eye and Motor Components of the Glasgow Coma Score As a Predictor of Extubation Failure in Patients with Acute Brain Injury |
| Authors: |
Taran, S; Perrot, B; Angriman, F; Cinotti, R; Abback, P; Codorniu, A; Citerio, G; Ludovica Sala, V; Astuto, M; Tringali, E; Alampi, D; Rocco, M; Giuseppina Maugeri, J; Bellissima, A; Filippini, M; Lazzeri, N; Cortegiani, A; Ippolito, M; Robba, C; Battaglini, D; Biston, P; Fathi Al-Gharyani, M; Chabanne, R; Astier, L; Soyer, B; Gaugain, S; Zimmerli, A; Pietsch, U; Filipovic, M; Brandi, G; Bicciato, G; Serrano, A; Monleon, B; Van Vliet, P; Marcel Gerretsen, B; Xochitl Ortiz-Macias, I; Oto, J; Enomoto, N; Matsuda, T; Masui, N; Garcon, P; Zarka, J; Vermeijden, W; Daniel Cornet, A; Reyes Inurrigarro, S; Cirino Lara Dominguez, R; Mercedes Bellini, M; Milagros Gomez Haedo, M; Lamot, L; Orquera, J; Biais, M; Georges, D; Baronia, A; Carlos Miranda-Ackerman, R; Jose Barbosa-Camacho, F; Porter, J; Lopez-Morales, M; Geeraerts, T; Compagnon, B; Perez-Torres, D; Prol-Silva, E; Basheer Yahya, H; Khaled, A; Ghula, M; Neville Andrea, C; Maria Daniela, P; Deana, C; Vetrugno, L; Rivera Chavez, M; Mendoza Trujillo, R; Legros, V; Brochet, B; Huet, O; Geslain, M; Van Der Jagt, M; Van Steenkiste, J; Ahmed, H; Edward Coombs, A; Welbourne, J; Velarde Pineda, A; Nubert Castillo, V; Azab, M; Azzam, A; Paul Van Meenen, D; Adrian Gasca, G; Arellano, A; Galicia-Espinosa, F; Carlos Garcia-Ramos, J; Yadav, G; Kumar Jha, A; Robert-Edan, V; Rodie-Talbere, P; Jain, G; Panda, S; Agarwal, S; Deewan, Y; Tariq Reza, S; Hossain, M; Papadas, C; Chantziara, V; Sklavou, C; Hourmant, Y; Grillot, N; Pirracchio, R; Akkari, A; Abdelaty, M; Hashim, A; Launey, Y; Masseret, E; Lasocki, S; Gergaud, S; Mouclier, N; Saxena, S; Agrawal, A; Bedanta Mishra, S; Samal, S; Cesar Mijangos, J; Haenggi, M; Gurjar, M; Schultz, M; Kaye, C; Agustin Godoy, D; Alvarez, P; Ioakeimidou, A; Ueno, Y; Badenes, R; Suei Elbuzidi, A; Piagnerelli, M; Elhadi, M; Atef Azab, M; Catherine Digitale, J; Fong, N; Campos Cerda, R; De La Torre Peredo, N; David Stevens, R; Taran S.; Perrot B.; Angriman F.; Cinotti R.; Abback P. -S.; Codorniu A.; Citerio G.; Ludovica Sala V.; Astuto M.; Tringali E.; Alampi D.; Rocco M.; Giuseppina Maugeri J.; Bellissima A.; Filippini M.; Lazzeri N.; Cortegiani A.; Ippolito M.; Robba C.; Battaglini D.; Biston P.; Fathi Al-Gharyani M.; Chabanne R.; Astier L.; Soyer B.; Gaugain S.; Zimmerli A.; Pietsch U.; Filipovic M.; Brandi G.; Bicciato G.; Serrano A.; Monleon B.; Van Vliet P.; Marcel Gerretsen B.; Xochitl Ortiz-Macias I.; Oto J.; Enomoto N.; Matsuda T.; Masui N.; Garcon P.; Zarka J.; Vermeijden W. J.; Daniel Cornet A.; Reyes Inurrigarro S.; Cirino Lara Dominguez R.; Mercedes Bellini M.; Milagros Gomez Haedo M.; Lamot L.; Orquera J.; Biais M.; Georges D.; Baronia A.; Carlos Miranda-Ackerman R.; Jose Barbosa-Camacho F.; Porter J.; Lopez-Morales M.; Geeraerts T.; Compagnon B.; Perez-Torres D.; Prol-Silva E.; Basheer Yahya H.; Khaled A.; Ghula M.; Neville Andrea C.; Maria Daniela P.; Deana C.; Vetrugno L.; Rivera Chavez M. J.; Mendoza Trujillo R.; Legros V.; Brochet B.; Huet O.; Geslain M.; Van Der Jagt M.; Van Steenkiste J.; Ahmed H.; Edward Coombs A.; Welbourne J.; Velarde Pineda A. A.; Nubert Castillo V. H.; Azab M. A.; Azzam A. Y.; Paul Van Meenen D. M.; Adrian Gasca G.; Arellano A.; Galicia-Espinosa F.; Carlos Garcia-Ramos J.; Yadav G.; Kumar Jha A.; Robert-Edan V.; Rodie-Talbere P. -A.; Jain G.; Panda S.; Agarwal S.; Deewan Y.; Tariq Reza S.; Hossain M. M.; Papadas C.; Chantziara V.; Sklavou C.; Hourmant Y.; Grillot N.; Pirracchio R.; Akkari A.; Abdelaty M.; Hashim A.; Launey Y.; Masseret E.; Lasocki S.; Gergaud S.; Mouclier N.; Saxena S.; Agrawal A.; Bedanta Mishra S.; Samal S.; Cesar Mijangos J.; Haenggi M.; Gurjar M.; Schultz M. J.; Kaye C.; Agustin Godoy D.; Alvarez P.; Ioakeimidou A.; Ueno Y.; Badenes R.; Suei Elbuzidi A. A.; Piagnerelli M.; Elhadi M.; Atef Azab M.; Catherine Digitale J.; Fong N.; Campos Cerda R.; De La Torre Peredo N.; David Stevens R. |
| Publisher Information: |
Lippincott Williams and Wilkins country:US 2024 |
| Document Type: |
Electronic Resource |
| Abstract: |
OBJECTIVES: To evaluate the association between the pre-extubation sum of eye and motor components of the Glasgow Coma Score (GCS-EM) and odds of extubation failure in patients with acute brain injury being liberated from mechanical ventilation. DESIGN: Secondary analysis of a prospective, multicenter observational study (ClinicalTrials.gov identifier NCT03400904). SETTING: Sixty-three hospital sites worldwide, with patient recruitment from January 2018 to November 2020. PATIENTS: One thousand one hundred fifty-two critically ill patients with acute brain injury, with a median age of 54 years, of whom 783 (68.0%) were male, 559 (48.5%) had traumatic brain injury, and 905 (78.6%) had a GCS-EM greater than 8 before extubation (scores range from 2 to 10). INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: GCS-EM was computed in intubated patients on the day of extubation. The main outcome was extubation failure, defined as unplanned reintubation within 5 days of extubation. Analyses used multilevel logistic regression with adjustment for patient characteristics and a random intercept for hospital site. In the primary analysis, GCS-EM was not associated with extubation failure (odds ratio, 1.07 per additional point; 95% CI, 0.87-1.31). Findings were consistent in sensitivity analyses that: 1) used different adjustment covariates, 2) included a verbal estimate to derive an overall GCS, 3) accounted for missing data, 4) considered a 2-day time interval to define extubation failure, 5) accounted for competing risks, and 6) used a propensity score-based model. There was no association between GCS-EM and extubation outcome in subgroups defined by brain injury diagnosis or age. CONCLUSIONS: In this large, contemporary, multicenter cohort of patients with acute brain injury, we found no association between the GCS-EM and odds of extubation failure. However, few patients had a pre-extubation GCS-EM less than or equal to 8, and the possibility of a true prognostic association i |
| Index Terms: |
acute brain injury; extubation failure; Glasgow Coma Score; mechanical ventilation; ventilator liberation; info:eu-repo/semantics/article |
| URL: |
https://hdl.handle.net/10281/501260; info:eu-repo/semantics/altIdentifier/pmid/38557684; info:eu-repo/semantics/altIdentifier/wos/WOS:001272373000002; volume:52; issue:8; firstpage:1258; lastpage:1263; numberofpages:6; journal:CRITICAL CARE MEDICINE |
| Availability: |
Open access content. Open access content |
| Note: |
STAMPA; English |
| Other Numbers: |
ITBAO oai:boa.unimib.it:10281/501260; 10.1097/CCM.0000000000006283; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85198995942; 1456741244 |
| Contributing Source: |
BICOCCA OPEN ARCH; From OAIster®, provided by the OCLC Cooperative. |
| Accession Number: |
edsoai.on1456741244 |
| Database: |
OAIster |