| Title: |
Pharmacologic agents directed at the treatment of pain associated with maladaptive neuronal plasticity |
| Authors: |
Pergolizzi, Joseph V.; Varrassi, Giustino; Magnusson, Peter; Breve, Frank; Raffa, Robert B.; Christo, Paul J.; Chopra, Maninder; Paladini, Antonella; LeQuang, Jo Ann; Mitchell, Kailyn; Coluzzi, Flaminia |
| Publisher Information: |
NEMA Research, Inc, Naples, USA Paolo Procacci Foundation, Rome, Italy Centre for Research and Development, Region Gävleborg/Uppsala University, Gävle, Sweden; Department of Medicine, Cardiology Research Unit, Karolinska Institutet, Stockholm, Sweden Department of Pharmacy Practice, Temple University School of Pharmacy, Philadelphia, USA College of Pharmacy (Adjunct), University of Arizona, Tucson, USA; Temple University School of Pharmacy (Professor Emeritus), Philadelphia, USA Johns Hopkins School of Medicine, Baltimore, USA Decision Alternatives, LLC, Frederick, USA Department MESVA, University of L'Aquila, L'Aquila, Italy NEMA Research, Inc, Naples, USA NEMA Research, Inc, Naples, USA Department Medical and Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy Ashley Mark Publishing Company 2022 |
| Document Type: |
Electronic Resource |
| Abstract: |
Introduction: The definition of nociplastic pain in 2016 has changed the way maladaptive chronic pain is viewed in that it may emerge without neural lesions or neural disease. Many endogenous and pharmacologic substances are being investigated for their role in treating the pain associated with neuronal plasticity. Areas Covered: The authors review promising pharmacologic agents for the treatment of pain associated with maladaptive neuronal plasticity. The authors then provide the reader with their expert opinion and provide their perspectives for the future. Expert opinion: An imbalance between the amplification of ascending pain signals and the poor activation of descending inhibitory signals may be at the root of many chronic pain syndromes. The inhibitory activity of noradrenaline reuptake may play a role in neuropathic and nociplastic analgesia. A better understanding of the brain's pain matrix, its signaling cascades, and the complex bidirectional communication between the immune system and the nervous system may help meet the urgent and unmet medical need for safe, effective chronic pain treatment, particularly for pain with a neuropathic and/or nociplastic component. |
| Index Terms: |
Neuropathic pain; nociplastic pain; maladaptive pain; microglial activation; pain matrix; neuroplasticity; Neurosciences; Neurovetenskaper; Article, review/survey; info:eu-repo/semantics/article; text |
| DOI: |
10.1080.14656566.2021.1970135 |
| URL: |
http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-122184; Expert Opinion on Pharmacotherapy, 1465-6566, 2022, 23:1, s. 105-116 |
| Availability: |
Open access content. Open access content; info:eu-repo/semantics/restrictedAccess |
| Note: |
English |
| Other Numbers: |
UPE oai:DiVA.org:oru-122184; 0000-0002-3822-2923; 0000-0001-7906-7782; 0000-0003-4794-0318; doi:10.1080/14656566.2021.1970135; PMID 34461795; ISI:000691503000001; Scopus 2-s2.0-85113990679; 1541809324 |
| Contributing Source: |
UPPSALA UNIV LIBR; From OAIster®, provided by the OCLC Cooperative. |
| Accession Number: |
edsoai.on1541809324 |
| Database: |
OAIster |