| Title: |
Lacosamide is Associated with a Higher Treatment Persistence at 12 Months than Brivaracetam and Perampanel Despite Similar Efficacy |
| Authors: |
Roberti, R; Politi, C; Anzellotti, F; Belcastro, V; Beretta, S; Boero, G; Bonanni, P; Canafoglia, L; D'Aniello, A; Dainese, F; De Caro, C; Di Gennaro, G; Di Giacomo, R; Di Francesco, J; Dono, F; Falcicchio, G; Ferlazzo, E; Foschi, N; Gambardella, A; Giordano, A; Labate, A; La Neve, A; Lattanzi, S; Leggio, U; Liguori, C; Maschio, M; Mattioli, P; Nilo, A; Operto, F; Pascarella, A; Pauletto, G; Pellegrino, L; Renna, R; Strigaro, G; Zoleo, P; Villani, F; Verriello, L; Tinti, L; Damavandi, P; Sensi, S; Pastori, C; Pascarella, M; Osanni, E; Olivieri, M; Mercuri, N; Maialetti, A; Lazzari, M; Gasparini, S; Fortunato, F; Fernandes, M; Evangelista, G; Deleo, F; Danieli, A; Cantello, R; Cagnetti, C; Buttarelli, L; Bedetti, C; Badioni, V; Arnaldi, D; Andreone, V; Russo, E; Roberti R.; Politi C.; Anzellotti F.; Belcastro V.; Beretta S.; Boero G.; Bonanni P.; Canafoglia L.; D'Aniello A.; Dainese F.; De Caro C.; Di Gennaro G.; Di Giacomo R.; Di Francesco J. C.; Dono F.; Falcicchio G.; Ferlazzo E.; Foschi N.; Gambardella A.; Giordano A.; Labate A.; La Neve A.; Lattanzi S.; Leggio U.; Liguori C.; Maschio M.; Mattioli P.; Nilo A.; Operto F. F.; Pascarella A.; Pauletto G.; Pellegrino L.; Renna R.; Strigaro G.; Zoleo P.; Villani F.; Verriello L.; Tinti L.; Damavandi P. T.; Sensi S. L.; Pastori C.; Pascarella M. G.; Osanni E.; Olivieri M.; Mercuri N. B.; Maialetti A.; Lazzari M.; Gasparini S.; Fortunato F.; Fernandes M.; Evangelista G.; Deleo F.; Danieli A.; Cantello R.; Cagnetti C.; Buttarelli L.; Bedetti C.; Badioni V.; Arnaldi D.; Andreone V.; Russo E. |
| Publisher Information: |
Adis country:GB 2026 |
| Document Type: |
Electronic Resource |
| Abstract: |
Introduction: Evidence directly comparing newer antiseizure medications (ASMs) is limited but crucial for guiding treatment decisions. This study compared the real-world effectiveness and tolerability of brivaracetam (BRV), lacosamide (LCM) and perampanel (PER) as add-on therapy in adults with epilepsy, applying a causal–inference extension of the COMPARE study. The aim of this approach was to overcome the limitations of standard multivariable analyses, better approximate causal effects, and reinforce the credibility of the results. Methods: Data were retrospectively collected in the Italian multicentre COMPARE study. To emulate a randomized setting, we estimated multinomial propensity scores and applied stabilized inverse probability weights. The primary analysis used a log-logistic accelerated failure time model to estimate time-to-treatment discontinuation, adjusting for adverse events (AEs), clinical response and follow-up duration. Secondary analyses evaluated changes in total and concomitant drug load and tolerability over time. Results: Among the 850 subjects included in this analysis (259, 240 and 351 receiving LCM, BRV and PER, respectively; 53.4% female; median age 43 years), the estimated probability of 12-month retention was highest for LCM (86.1%), followed by BRV (79.1%) and PER (75.4%). Long-term trends suggested convergence of PER and LCM retention, whereas BRV discontinuation remained higher. In the adjusted analyses, BRV and PER were associated with shorter time-to-treatment discontinuation than LCM, but this negative effect decreased over time, while the beneficial effect of clinical response strengthened. Total drug load increased across all groups but remained lowest for LCM; concomitant ASM load decreased, particularly among responders. AEs were mostly mild, with dizziness, irritability and somnolence the most common AEs. AE rates were initially higher for PER and BRV, but differences diminished over time. Conclusion: Treatment discontinua |
| Index Terms: |
Antiseizure medication; Comparative analysi; Drug load; Epilepsy; Real world study; Retention rate; Safety; info:eu-repo/semantics/article |
| URL: |
https://hdl.handle.net/10281/592205; info:eu-repo/semantics/altIdentifier/pmid/41264217; info:eu-repo/semantics/altIdentifier/wos/WOS:001619004600001; volume:15; issue:1; firstpage:213; lastpage:235; numberofpages:23; journal:NEUROLOGY AND THERAPY |
| Availability: |
Open access content. Open access content; info:eu-repo/semantics/openAccess; license:Creative Commons; license uri:http://creativecommons.org/licenses/by-nc/4.0 |
| Note: |
STAMPA; English |
| Other Numbers: |
ITBAO oai:boa.unimib.it:10281/592205; 10.1007/s40120-025-00860-5; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-105025103225; 1574047355 |
| Contributing Source: |
BICOCCA OPEN ARCH; From OAIster®, provided by the OCLC Cooperative. |
| Accession Number: |
edsoai.on1574047355 |
| Database: |
OAIster |