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A dihydrouracil CRBN ligand mitigates IMiD associated safety liabilities in heterobifunctional targeted protein degrader

Title: A dihydrouracil CRBN ligand mitigates IMiD associated safety liabilities in heterobifunctional targeted protein degrader
Authors: Rodrigo-Brenni, Monica C.Aff1; Komen, Jasper C.Aff1; Hamza, Ghaith M.Aff2; Bohin, NatachaAff1; Adomavicius, TomasAff3; Andres, AngeloAff2; Blaho, StefanAff4; Börjesson, UlfAff5; Collie, Gavin W.Aff3; De Donatis, Gian MarcoAff6; Eisele, FrederikAff7; Gao, NingAff2; Gohlke, AndreaAff3; Grebner, ChristophAff5; Gustafsson, FridaAff1; Hock, AndreasAff6; Kankkonen, CeciliaAff7; Kumar, PraveenAff8; Leonard, EmilyanneAff9; Li, XinAff10; Macdonald, RuthAff11; Madeyski-Bengtson, KatjaAff12; Miele, EricAff2; Nevin, PhilipAff7; Overman, JeroenAff6; Pachl, FionaAff2; Pathe, ClaudioAff6; Perry, Matthew W. D.Aff13; Phillips, ChristopherAff3; Pike, AndyAff14; Purvis, IanAff11; Rasmusson, TimothyAff2; Regan, SophieAff1; Reilly, LindaAff1; Rose, JonathanAff11; Storer, R. IanAff15; Wang, JingwenAff10; Zhai, XiangAff2; Michaelides, Iacovos N.Aff15, IDs41467026706631_cor1; Moreau, KevinAff1, IDs41467026706631_cor2
Source: Nature Communications. 17(1)
Database: Springer Nature Journals