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Investigational eIF2B activator DNL343 modulates the integrated stress response in preclinical models of TDP-43 pathology and individuals with ALS in a randomized clinical trial

Title:	Investigational eIF2B activator DNL343 modulates the integrated stress response in preclinical models of TDP-43 pathology and individuals with ALS in a randomized clinical trial
Authors:	Flores, Brittany N.^{Aff1, Aff11}; Yu, Seungyoon B.^Aff1; Cohen, Isaac V.^Aff1; Fanok, Melania H.^Aff1; Luan, Wei^Aff2; Maciuca, Romeo D.^Aff1; Sun, Linus D.^{Aff1, Aff12}; Tsai, Richard M.^Aff1; Vissers, Maurits^Aff3; Smits, Lars^{Aff3, Aff4}; Bunte, Tommy M.^Aff5; Bakardjiev, Anna^{Aff1, Aff13}; Balasundar, Srijana^Aff1; Calvert, Meredith E. K.^Aff1; Chin, Marcus Y.^Aff1; Dobbins, Sarah K.^Aff1; Dowdle, William E.^{Aff1, Aff14}; Fang, Meng^Aff1; Heuberger, Jules A. A. C.^Aff3; Ha, Connie L.^Aff1; Huang, Fen^{Aff1, Aff15}; Miyamoto, Takashi^Aff1; Osipov, Maksim^{Aff1, Aff16}; Madrid San Martin, Lidia^Aff2; Saund, Katie^Aff1; Tatarakis, David^Aff1; Vu, Anthony Q.^Aff6; Xiong, Chenling^{Aff1, Aff13}; Yeo, Gene W.^{Aff6, Aff7, Aff8, Aff9}; Groeneveld, Geert Jan^{Aff3, Aff4}; van den Berg, Leonard H.^Aff5; Dhuria, Shyeilla^Aff1; Estrada, Anthony A.^{Aff1, Aff17}; Jennings, Danna^Aff1; Sandmann, Thomas^Aff1; Ho, Carole^Aff1; Scearce-Levie, Kimberly^{Aff1, Aff15}; Yulyaningsih, Ernie^{Aff1, Aff17}; Walker, Adam K.^{Aff2, Aff10}; Di Paolo, Gilbert^{Aff1, IDs4146702563031y_cor1}; Kane, Lesley A.^{Aff1, IDs4146702563031y_cor2}; Troyer, Matthew D.^{Aff1, IDs4146702563031y_cor3}; Lewcock, Joseph W.^{Aff1, IDs4146702563031y_cor4}
Source:	Nature Communications. 16(1)
Database:	Springer Nature Journals