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Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

Title:	Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes
Authors:	Malik, Rainer^Aff1; Chauhan, Ganesh^Aff2; Traylor, Matthew^Aff3; Sargurupremraj, Muralidharan^{Aff4, Aff5}; Okada, Yukinori^{Aff6, Aff7, Aff8}; Mishra, Aniket^{Aff4, Aff5}; Rutten-Jacobs, Loes^Aff3; Giese, Anne-Katrin^Aff9; van der Laan, Sander W.^Aff10; Gretarsdottir, Solveig^Aff11; Anderson, Christopher D.^{Aff12, Aff13, Aff14}; Chong, Michael^Aff15; Adams, Hieab H. H.^{Aff16, Aff17}; Ago, Tetsuro^Aff18; Almgren, Peter^Aff19; Amouyel, Philippe^{Aff20, Aff21}; Ay, Hakan^{Aff13, Aff22}; Bartz, Traci M.^Aff23; Benavente, Oscar R.^Aff24; Bevan, Steve^Aff25; Boncoraglio, Giorgio B.^Aff26; Brown, Robert D.^Aff27; Butterworth, Adam S.^{Aff28, Aff29}; Carrera, Caty^{Aff30, Aff31}; Carty, Cara L.^{Aff32, Aff33}; Chasman, Daniel I.^{Aff34, Aff35}; Chen, Wei-Min^Aff36; Cole, John W.^Aff37; Correa, Adolfo^Aff38; Cotlarciuc, Ioana^Aff39; Cruchaga, Carlos^{Aff40, Aff41}; Danesh, John^{Aff28, Aff42, Aff43, Aff44}; de Bakker, Paul I. W.^{Aff45, Aff46}; DeStefano, Anita L.^{Aff47, Aff48}; den Hoed, Marcel^Aff49; Duan, Qing^Aff50; Engelter, Stefan T.^{Aff51, Aff52}; Falcone, Guido J.^{Aff53, Aff54}; Gottesman, Rebecca F.^Aff55; Grewal, Raji P.^Aff56; Gudnason, Vilmundur^{Aff57, Aff58}; Gustafsson, Stefan^Aff59; Haessler, Jeffrey^Aff60; Harris, Tamara B.^Aff61; Hassan, Ahamad^Aff62; Havulinna, Aki S.^{Aff63, Aff64}; Heckbert, Susan R.^Aff65; Holliday, Elizabeth G.^{Aff66, Aff67}; Howard, George^Aff68; Hsu, Fang-Chi^Aff69; Hyacinth, Hyacinth I.^Aff70; Ikram, M. Arfan^Aff16; Ingelsson, Erik^{Aff71, Aff72}; Irvin, Marguerite R.^Aff73; Jian, Xueqiu^Aff74; Jiménez-Conde, Jordi^Aff75; Johnson, Julie A.^{Aff76, Aff77}; Jukema, J. Wouter^Aff78; Kanai, Masahiro^{Aff6, Aff7, Aff79}; Keene, Keith L.^{Aff80, Aff81}; Kissela, Brett M.^Aff82; Kleindorfer, Dawn O.^Aff82; Kooperberg, Charles^Aff60; Kubo, Michiaki^Aff83; Lange, Leslie A.^Aff84; Langefeld, Carl D.^Aff85; Langenberg, Claudia^Aff86; Launer, Lenore J.^Aff87; Lee, Jin-Moo^Aff88; Lemmens, Robin^{Aff89, Aff90}; Leys, Didier^Aff91; Lewis, Cathryn M.^{Aff92, Aff93}; Lin, Wei-Yu^{Aff28, Aff94}; Lindgren, Arne G.^{Aff95, Aff96}; Lorentzen, Erik^Aff97; Magnusson, Patrik K.^Aff98; Maguire, Jane^Aff99; Manichaikul, Ani^Aff36; McArdle, Patrick F.^Aff100; Meschia, James F.^Aff101; Mitchell, Braxton D.^{Aff100, Aff102}; Mosley, Thomas H.^{Aff103, Aff104}; Nalls, Michael A.^{Aff105, Aff106}; Ninomiya, Toshiharu^Aff107; O’Donnell, Martin J.^{Aff15, Aff108}; Psaty, Bruce M.^{Aff109, Aff110, Aff111, Aff112}; Pulit, Sara L.^{Aff45, Aff113}; Rannikmäe, Kristiina^{Aff114, Aff115}; Reiner, Alexander P.^{Aff65, Aff116}; Rexrode, Kathryn M.^Aff117; Rice, Kenneth^Aff118; Rich, Stephen S.^Aff36; Ridker, Paul M.^{Aff34, Aff35}; Rost, Natalia S.^{Aff9, Aff13}; Rothwell, Peter M.^Aff119; Rotter, Jerome I.^{Aff120, Aff121}; Rundek, Tatjana^Aff122; Sacco, Ralph L.^Aff122; Sakaue, Saori^{Aff7, Aff123}; Sale, Michele M.^Aff124; Salomaa, Veikko^Aff63; Sapkota, Bishwa R.^Aff125; Schmidt, Reinhold^Aff126; Schmidt, Carsten O.^Aff127; Schminke, Ulf^Aff128; Sharma, Pankaj^Aff39; Slowik, Agnieszka^Aff129; Sudlow, Cathie L. M.^{Aff114, Aff115}; Tanislav, Christian^Aff130; Tatlisumak, Turgut^{Aff131, Aff132}; Taylor, Kent D.^{Aff120, Aff121}; Thijs, Vincent N. S.^{Aff133, Aff134}; Thorleifsson, Gudmar^Aff11; Thorsteinsdottir, Unnur^Aff11; Tiedt, Steffen^Aff1; Trompet, Stella^Aff135; Tzourio, Christophe^{Aff5, Aff136, Aff137}; van Duijn, Cornelia M.^{Aff138, Aff139}; Walters, Matthew^Aff140; Wareham, Nicholas J.^Aff86; Wassertheil-Smoller, Sylvia^Aff141; Wilson, James G.^Aff142; Wiggins, Kerri L.^Aff109; Yang, Qiong^Aff47; Yusuf, Salim^Aff15; Bis, Joshua C.^Aff109; Pastinen, Tomi^Aff144; Ruusalepp, Arno^{Aff145, Aff146, Aff147}; Schadt, Eric E.^Aff148; Koplev, Simon^Aff148; Björkegren, Johan L. M.^{Aff148, Aff149, Aff150, Aff151}; Codoni, Veronica^{Aff152, Aff153}; Civelek, Mete^{Aff124, Aff154}; Smith, Nicholas L.^{Aff65, Aff155, Aff156}; Trégouët, David A.^{Aff152, Aff153}; Christophersen, Ingrid E.^{Aff54, Aff157, Aff158}; Roselli, Carolina^Aff54; Lubitz, Steven A.^{Aff54, Aff157}; Ellinor, Patrick T.^{Aff54, Aff157}; Tai, E. Shyong^Aff159; Kooner, Jaspal S.^Aff160; Kato, Norihiro^Aff161; He, Jiang^Aff162; van der Harst, Pim^Aff163; Elliott, Paul^Aff164; Chambers, John C.^{Aff165, Aff166}; Takeuchi, Fumihiko^Aff161; Johnson, Andrew D.^{Aff48, Aff167}; Sanghera, Dharambir K.^{Aff125, Aff169, Aff170}; Melander, Olle^Aff19; Jern, Christina^Aff171; Strbian, Daniel^{Aff172, Aff173}; Fernandez-Cadenas, Israel^{Aff30, Aff31}; Longstreth, W. T.^{Aff65, Aff174}; Rolfs, Arndt^Aff175; Hata, Jun^Aff107; Woo, Daniel^Aff82; Rosand, Jonathan^{Aff12, Aff13, Aff14}; Pare, Guillaume^Aff15; Hopewell, Jemma C.^Aff176; Saleheen, Danish^Aff177; Stefansson, Kari^{Aff11, Aff178}; Worrall, Bradford B.^Aff179; Kittner, Steven J.^Aff37; Seshadri, Sudha^{Aff48, Aff180}; Fornage, Myriam^{Aff74, Aff181}; Markus, Hugh S.^Aff3; Howson, Joanna M. M.^Aff28; Kamatani, Yoichiro^{Aff6, Aff182}; Debette, Stephanie^{Aff4, Aff5, IDs4158801800583_cor185}; Dichgans, Martin^{Aff1, Aff183, Aff184, IDs4158801800583_cor186}; Traylor, Matthew^Aff3; Okada, Yukinori^{Aff6, Aff7, Aff8}; Rutten-Jacobs, Loes^Aff3; van der Laan, Sander W.^Aff10; Almgren, Peter^Aff19; Amouyel, Philippe^{Aff20, Aff21}; Correa, Adolfo^Aff38; Cruchaga, Carlos^{Aff40, Aff41}; Hoed, Marcel den^Aff49; Gustafsson, Stefan^Aff59; Havulinna, Aki S.^{Aff63, Aff64}; Jukema, J. Wouter^Aff78; Kanai, Masahiro^{Aff6, Aff7, Aff79}; Lewis, Cathryn M.^{Aff92, Aff93}; Lin, Wei-Yu^{Aff28, Aff94}; Wiggins, Kerri L.^Aff109; Yang, Qiong^Aff47; Amin, Najaf^Aff16; Aparicio, Hugo S.^{Aff48, Aff187}; Arnett, Donna K.^Aff188; Attia, John^Aff189; Beiser, Alexa S.^{Aff47, Aff48}; Berr, Claudine^Aff190; Buring, Julie E.^{Aff34, Aff35}; Bustamante, Mariana^Aff191; Caso, Valeria^Aff192; Cheng, Yu-Ching^Aff193; Choi, Seung Hoan^{Aff48, Aff194}; Chowhan, Ayesha^{Aff48, Aff187}; Cullell, Natalia^Aff31; Dartigues, Jean-François^{Aff195, Aff196}; Delavaran, Hossein^{Aff95, Aff96}; Delgado, Pilar^Aff197; Dörr, Marcus^{Aff198, Aff199}; Engström, Gunnar^Aff19; Ford, Ian^Aff200; Gurpreet, Wander S.^Aff201; Hamsten, Anders^{Aff202, Aff203}; Heitsch, Laura^Aff204; Hozawa, Atsushi^Aff205; Ibanez, Laura^Aff206; Ilinca, Andreea^{Aff95, Aff96}; Ingelsson, Martin^Aff207; Iwasaki, Motoki^Aff208; Jackson, Rebecca D.^Aff209; Jood, Katarina^Aff210; Jousilahti, Pekka^Aff63; Kaffashian, Sara^{Aff4, Aff5}; Kalra, Lalit^Aff211; Kamouchi, Masahiro^Aff212; Kitazono, Takanari^Aff213; Kjartansson, Olafur^Aff214; Kloss, Manja^Aff215; Koudstaal, Peter J.^Aff216; Krupinski, Jerzy^Aff217; Labovitz, Daniel L.^Aff218; Laurie, Cathy C.^Aff118; Levi, Christopher R.^Aff219; Li, Linxin^Aff220; Lind, Lars^Aff221; Lindgren, Cecilia M.^{Aff222, Aff223}; Lioutas, Vasileios^{Aff48, Aff224}; Liu, Yong Mei^Aff225; Lopez, Oscar L.^Aff226; Makoto, Hirata^Aff227; Martinez-Majander, Nicolas^Aff172; Matsuda, Koichi^Aff227; Minegishi, Naoko^Aff205; Montaner, Joan^Aff228; Morris, Andrew P.^{Aff229, Aff230}; Muiño, Elena^Aff31; Müller-Nurasyid, Martina^{Aff231, Aff232, Aff233}; Norrving, Bo^{Aff95, Aff96}; Ogishima, Soichi^Aff205; Parati, Eugenio A.^Aff234; Peddareddygari, Leema Reddy^Aff56; Pedersen, Nancy L.^{Aff98, Aff235}; Pera, Joanna^Aff129; Perola, Markus^{Aff63, Aff236}; Pezzini, Alessandro^Aff237; Pileggi, Silvana^Aff238; Rabionet, Raquel^Aff239; Riba-Llena, Iolanda^Aff30; Ribasés, Marta^Aff240; Romero, Jose R.^{Aff48, Aff187}; Roquer, Jaume^{Aff241, Aff242}; Rudd, Anthony G.^{Aff243, Aff244}; Sarin, Antti-Pekka^{Aff245, Aff246}; Sarju, Ralhan^Aff201; Sarnowski, Chloe^{Aff47, Aff48}; Sasaki, Makoto^Aff247; Satizabal, Claudia L.^{Aff48, Aff187}; Satoh, Mamoru^Aff247; Sattar, Naveed^Aff248; Sawada, Norie^Aff208; Sibolt, Gerli^Aff172; Sigurdsson, Ásgeir^Aff249; Smith, Albert^Aff250; Sobue, Kenji^Aff247; Soriano-Tárraga, Carolina^Aff242; Stanne, Tara^Aff251; Stine, O. Colin^Aff252; Stott, David J.^Aff253; Strauch, Konstantin^{Aff231, Aff254}; Takai, Takako^Aff205; Tanaka, Hideo^{Aff255, Aff256}; Tanno, Kozo^Aff247; Teumer, Alexander^Aff257; Tomppo, Liisa^Aff172; Torres-Aguila, Nuria P.^Aff31; Touze, Emmanuel^{Aff258, Aff259}; Tsugane, Shoichiro^Aff208; Uitterlinden, Andre G.^Aff260; Valdimarsson, Einar M.^Aff261; van der Lee, Sven J.^Aff16; Völzke, Henry^Aff257; Wakai, Kenji^Aff255; Weir, David^Aff262; Williams, Stephen R.^Aff263; Wolfe, Charles D. A.^{Aff243, Aff244}; Wong, Quenna^Aff118; Xu, Huichun^Aff193; Yamaji, Taiki^Aff208; Jern, Christina^Aff171; Saleheen, Danish^Aff177; Kamatani, Yoichiro^{Aff6, Aff182}; Debette, Stephanie^{Aff4, Aff5}; Dichgans, Martin^{Aff1, Aff183, Aff184}
Source:	Nature Genetics. 50(4):524-537
Database:	Springer Nature Journals