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1
Towards the design of ligands of the internal pocket TEADs C-terminal domain

von Toulotte, Florine ; Coevoet, Mathilde ; Liberelle, Maxime ; et al.

In European Journal of Medicinal Chemistry 15 January 2025 282
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2
Incidence, prevalence and clinical presentation of inflammatory bowel diseases in Northern France: a 30-year population-based studyResearch in context

von Hélène Sarter ; Thibaut Crétin ; Guillaume Savoye ; et al.

The Lancet Regional Health. Europe, Vol 47, Iss , Pp 101097- (2024)

Schlagworte: Inflammatory bowel disease; Incidence; Prevalence; Population-based registry; Crohn’s disease; Ulcerative colitis; Public aspects of medicine; RA1-1270
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3
Novel Quinazoline Derivatives as Highly Effective A2A Adenosine Receptor Antagonists.

von Laversin, Amelie ; Dufossez, Robin ; Bolteau, R. ; et al.
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4
High ligand efficiency quinazoline compounds as novel A2A adenosine receptor antagonists

von Bolteau, Raphaël ; Duroux, Romain ; Laversin, Amélie ; et al.

In European Journal of Medicinal Chemistry 5 November 2022 241
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5
Pharmacomodulations around an anti-Alzheimer drug-candidate

von Marc, Sylvain ; Mésangeau, Christophe ; Coevoet, Mathilde ; et al.

In European Journal of Medicinal Chemistry Reports April 2022 4
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6
Novel Quinazoline Derivatives as Highly Effective A2A Adenosine Receptor Antagonists.

von Laversin, Amelie ; Dufossez, Robin ; Bolteau, R. ; et al.

ISSN: 1420-3049 ; Molecules ; https://hal.univ-lille.fr/hal-04977456 ; Molecules, 2024, Molecules, 29 (16), pp.3847. ⟨10.3390/molecules29163847⟩.

Schlagworte: [SDV]Life Sciences [q-bio]
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7
Discovery of Compounds That Selectively Repress the Amyloidogenic Processing of the Amyloid Precursor Protein: Design, Synthesis and Pharmacological Evaluation of Diphenylpyrazoles.

von Mesangeau, Christophe ; Carato, Pascal ; Renault, Nicolas ; et al.

Schlagworte: Alzheimer's disease; amyloid protein precursor; lysosome; autophagy; beta-secretase; pyrazole
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8
New phenylaniline derivatives as modulators of amyloid protein precursor metabolism

von Gay, Marion ; Carato, Pascal ; Coevoet, Mathilde ; et al.

Schlagworte: Phenylanilines; Amyloid; Polyamines; Abeta peptides
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9
Discovery of a cryptic site at the interface 2 of TEAD – Towards a new family of YAP/TAZ-TEAD inhibitors

von Sturbaut, Manon ; Bailly, Fabrice ; Coevoet, Mathilde ; et al.

In European Journal of Medicinal Chemistry 15 December 2021 226
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10
A phenotypic approach to the discovery of compounds that promote non-amyloidogenic processing of the amyloid precursor protein: toward a new profile of indirect ?-secretase inhibitors

von Gay, Marion ; Evrard, Caroline ; Descamps, Florian ; et al.

Schlagworte: Lysosome; beta-secretase; BACE-1; Indirect inhibitor; Alzheimer's disease; Phenotypic; Amyloid precursor protein; Chloroquine; Autophagy
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11
Design and synthesis of 2,6-disubstituted-8-amino imidazo[1,2a]pyridines, a promising privileged structure

von Boulahjar, Rajaa ; Rincon Arias, Angela ; Bolteau, Raphael ; et al.

Schlagworte: Amino-imidazopyridine; Privileged structure; Palladium-catalyzed coupling reaction; A(2A) receptor
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12
New piperazine multi-effect drugs prevent neurofibrillary degeneration and amyloid deposition, and preserve memory in animal models of Alzheimer's disease

von Sergeant, Nicolas ; Vingtdeux, Valérie ; Eddarkaoui, Sabiha ; et al.

In Neurobiology of Disease September 2019 129:217-233
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13
Discovery of Compounds That Selectively Repress the Amyloidogenic Processing of the Amyloid Precursor Protein: Design, Synthesis and Pharmacological Evaluation of Diphenylpyrazoles

von Mesangeau, Christophe ; Carato, Pascal ; Renault, Nicolas ; et al.

ISSN: 1661-6596.

Schlagworte: Alzheimer's disease; amyloid protein precursor; lysosome; autophagy; β-secretase; pyrazole; [CHIM]Chemical Sciences
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14
A phenotypic approach to the discovery of compounds that promote non-amyloidogenic processing of the amyloid precursor protein: Toward a new profile of indirect β-secretase inhibitors

von Gay, Marion ; Evrard, Caroline ; Descamps, Florian ; et al.

In European Journal of Medicinal Chemistry 5 November 2018 159:104-125
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15
Design and synthesis of 2,6-disubstituted-8-amino imidazo[1,2a]pyridines, a promising privileged structure

von Boulahjar, Rajaa ; Rincon Arias, Angela ; Bolteau, Raphaël ; et al.

In Bioorganic & Medicinal Chemistry 23 July 2018 26(12):3296-3307
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16
New phenylaniline derivatives as modulators of amyloid protein precursor metabolism

von Gay, Marion ; Carato, Pascal ; Coevoet, Mathilde ; et al.

In Bioorganic & Medicinal Chemistry 1 May 2018 26(8):2151-2164
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17
Incidence and risk factors for thromboembolic events in pediatric-onset inflammatory bowel disease: A French population-based study

von Najib, AL GHOSSAINI ; Raied, AL HAMEEDI ; Saria, AL TURK ; et al.

In Digestive and Liver Disease September 2024
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18
Low incidence of SARS-CoV-2, risk factors of mortality and the course of illness in the French national cohort of dialysis patients

von Abbassi, Abdelhamid ; Debure, Alain ; Guerraoui, Abdallah ; et al.

In Kidney International December 2020 98(6):1519-1529
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19
Toward the Discovery of a Novel Class of YAP⁻TEAD Interaction Inhibitors by Virtual Screening Approach Targeting YAP⁻TEAD Protein⁻Protein Interface.

von Gibault, Floriane ; Coevoet, Mathilde ; Sturbaut, Manon ; et al.
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20
Design, Synthesis and Evaluation of a Series of 1,5‐Diaryl‐1,2,3‐triazole‐4‐carbohydrazones as Inhibitors of the YAP‐TAZ/TEAD Complex

von Gibault, Floriane ; Sturbaut, Manon ; Coevoet, Mathilde ; et al.

ChemMedChem ; volume 16, issue 18, page 2823-2844 ; ISSN 1860-7179 1860-7187
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21
Contribution of the Endosomal-Lysosomal and Proteasomal Systems in Amyloid-β Precursor Protein Derived Fragments Processing

von Caroline Evrard ; Pascal Kienlen-Campard ; Mathilde Coevoet ; et al.

Frontiers in Cellular Neuroscience, Vol 12 (2018)

Schlagworte: Alzheimer’s disease; amyloid precursor protein; amyloid beta peptide; APP-CTF; C99; Neurosciences. Biological psychiatry. Neuropsychiatry; RC321-571
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22
Toward the Discovery of a Novel Class of YAP–TEAD Interaction Inhibitors by Virtual Screening Approach Targeting YAP–TEAD Protein–Protein Interface

von Gibault, Floriane ; Coevoet, Mathilde ; Sturbaut, Manon ; et al.

ISSN: 2072-6694.

Schlagworte: binding assays; molecular docking; protein-protein interaction; anticancer; YAP-TEAD disruption; [CHIM.THER]Chemical Sciences/Medicinal Chemistry; [CHIM.CHEM]Chemical Sciences/Cheminformatics; [SDV.CAN]Life Sciences [q-bio]/Cancer
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23
Molecular Features of the YAP Inhibitor Verteporfin: Synthesis of Hexasubstituted Dipyrrins as Potential Inhibitors of YAP/TAZ, the Downstream Effectors of the Hippo Pathway

von Gibault, Floriane ; Bailly, Fabrice ; Corvaisier, Mathieu ; et al.

ISSN: 1860-7179.

Schlagworte: [CHIM.THER]Chemical Sciences/Medicinal Chemistry; [CHIM.ORGA]Chemical Sciences/Organic chemistry; [SDV.CAN]Life Sciences [q-bio]/Cancer
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24
Novel Quinazoline Derivatives as Highly Effective a 2a Adenosine Receptor Antagonists

von Laversin, Amélie ; Dufossez, Robin ; Bolteau, Raphaël ; et al.
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25
Incidence, prevalence and clinical presentation of inflammatory bowel diseases in Northern France: a 30-year population-based study

von Sarter, Hélène ; Crétin, Thibaut ; Savoye, Guillaume ; et al.

Schlagworte: Crohn’s disease; Incidence; Inflammatory bowel disease; Population-based registry; Prevalence; Ulcerative colitis
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