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  • 1

    von Lumry WR ; Tachdjian R ; Craig T ; et al.

    Journal of Asthma and Allergy, Vol 19, Iss Issue 1, Pp 1-12 (2026)

    Schlagworte: Background: Donidalorsen; a prekallikrein-directed antisense oligonucleotide indicated for prophylaxis of hereditary angioedema (HAE) attacks in patients aged ≥12 years; demonstrated efficacy and acceptable safety in the phase 3; placebo-controlled OASIS-HAE trial (NCT05139810). Here; we report 1-year results from the corresponding open-label extension (OLE) cohort of the OASISplus study (NCT05392114). Methods: OASISplus included patients who rolled over from OASIS-HAE. Patients who received donidalorsen 80 mg or placebo subcutaneously every 4 weeks (Q4W) in OASIS-HAE received donidalorsen Q4W in OASISplus. Patients who received donidalorsen 80 mg or placebo every 8 weeks (Q8W) in OASIS-HAE received donidalorsen Q8W or Q4W; if not attack-free in the final 8 weeks of OASIS-HAE. The primary endpoint was safety (ie; Immunologic diseases. Allergy; RC581-607

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  • 13

    von Winkler, TW ; Justice, AE ; Graff, M ; et al.

    Winkler, TW, Justice, AE, Graff, M, Barata, L, Feitosa, MF, Chu, S, Czajkowski, J, Esko, T, Fall, T, Kilpelainen, TO, Lu, YC, Magi, R, Mihailov, E, Pers, TH, Rueger, S, Teumer, A, Ehret, GB, Ferreira, T, Heard-Costa, NL, Karjalainen, J, Lagou, V, Mahajan, A, Neinast, MD, Prokopenko, I, Simino, J, Teslovich, TM, Jansen, R, Westra, HJ, White, CC, Absher, D, Ahluwalia, TS, Ahmad, S, Albrecht, E, Alves, AC, Bragg-Gresham, JL, de Craen, AJM, Bis, JC, Bonnefond, A, Boucher, G, Cadby, G, Cheng, YC, Chiang, CWK, Delgado, G, Demirkan, A, Dueker, N, Eklund, N, Eiriksdottir, G, Eriksson, J, Feenstra, B, ....

    Schlagworte: /dk/atira/pure/keywords/researchprograms/AFL001000/EMCNIHES016402; name=EMC NIHES-01-64-02; /dk/atira/pure/keywords/researchprograms/AFL001000/EMCOR013908; name=EMC OR-01-39-08

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