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  • 8

    Schlagworte: Biochemistry; Genetics; Pharmacology; Sociology; Inorganic Chemistry; Environmental Sciences not elsewhere classified; Biological Sciences not elsewhere classified; Mathematical Sciences not elsewhere classified; Chemical Sciences not elsewhere classified; Information Systems not elsewhere classified; value ≤ 0; performed significantly better; nine mies modeled; new bioinformatic approaches; machine learning approach; identifies reference chemicals; glucocorticoid receptor agonism; extracting mechanistic insight; excluded reference chemicals; estrogen receptor agonism; correctly predicted mies; 1750 test chemicals; chemical safety information; chemical hazard identification; generate mie predictions; transcriptomic data sets; three yielded classifiers; framework trains models; reference chemical exposures; l

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  • 23

    Schlagworte: Biochemistry; Genetics; Molecular Biology; Immunology; Developmental Biology; Cancer; Biological Sciences not elsewhere classified; transcriptomics technologies allow; different read depths; average pearson correlation; 76 &# 8211; gene ontologies annotated; cellular structure functions; pearson correlation 0; concordant expression levels; 90 – 0; 810 genes ); 290 genes within; principal component analysis; div >< p; calculating relative log; normalized expression data; seq data sets; seq rle data; seq data; ribosomal functions; ontologies associated; data acquisition; 480 genes; well correlated

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  • 25

    Schlagworte: Biochemistry; Genetics; Molecular Biology; Immunology; Developmental Biology; Cancer; Biological Sciences not elsewhere classified; transcriptomics technologies allow; different read depths; average pearson correlation; 76 &# 8211; gene ontologies annotated; cellular structure functions; pearson correlation 0; concordant expression levels; 90 – 0; 810 genes ); 290 genes within; principal component analysis; div >< p; calculating relative log; normalized expression data; seq data sets; seq rle data; seq data; ribosomal functions; ontologies associated; data acquisition; 480 genes; well correlated

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