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12 3 4 5 6 7 weiter »

1
Proteomic prediction of diverse incident diseases: a machine learning-guided biomarker discovery study using data from a prospective cohort study.

von Carrasco-Zanini, J ; Pietzner, M ; Koprulu, M ; et al.

Schlagworte: Humans; Middle Aged; Machine Learning; Male; Female; Prospective Studies; Biomarkers; Proteomics; Aged; Adult; England; Risk Assessment; Risk Factors
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2
Multi-omic prediction of incident type 2 diabetes.

von Carrasco-Zanini, J ; Pietzner, M ; Wheeler, E ; et al.

Schlagworte: Biomarkers; Genomics; Metabolomics; Prediction models; Proteomics; Type 2 diabetes; Humans; Diabetes Mellitus; Type 2; Prediabetic State; Prospective Studies; Cohort Studies; Proteome; Multiomics; Risk Factors
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3
Causal associations between cardiorespiratory fitness and type 2 diabetes

von Cai, L ; Gonzales, T ; Wheeler, E ; et al.
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4
Sex differences in the genetic regulation of the human plasma proteome

von Koprulu, M ; Wheeler, E ; Kerrison, ND ; et al.

Schlagworte: Humans; Blood Proteins; Proteome; Cohort Studies; Sex Factors; Gene Expression Regulation; Sex Characteristics; Quantitative Trait Loci; Middle Aged; Female; Male; Article
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5
Damaging missense variants in IGF1R implicate a role for IGF-1 resistance in the etiology of type 2 diabetes.

von Gardner, EJ ; Kentistou, KA ; Stankovic, S ; et al.

Schlagworte: IGF1; Mendelian randomization; UK Biobank; exome-wide association study; type 2 diabetes
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6
Synergistic insights into human health from aptamer- and antibody-based proteomic profiling

von Pietzner, M ; Wheeler, E ; Carrasco-Zanini, J ; et al.

Nature Communications , 12 (1) , Article 6822. (2021)

Schlagworte: Blood proteins; Diseases; Proteomic analysis; Quantitative trait loci
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7
Mapping the proteo-genomic convergence of human diseases

von Pietzner, M ; Wheeler, E ; Carrasco-Zanini, J ; et al.

Science , 374 (6569) , Article eabj1541. (2021)
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8
Genetic architecture of host proteins involved in SARS-CoV-2 infection (vol 11, 6397, 2020)

von Pietzner, M ; Wheeler, E ; Carrasco-Zanini, J ; et al.
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9
GIGYF1 loss of function is associated with clonal mosaicism and adverse metabolic health

von Zhao, Y ; Stankovic, S ; Koprulu, M ; et al.
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10
Epigenome-Wide Association Study of Incident Type 2 Diabetes in a British Population: EPIC-Norfolk Study

von Cardona, A ; Day, FR ; Perry, JRB ; et al.
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11
Genetic architecture of host proteins involved in SARS-CoV-2 infection

von Pietzner, Maik ; Wheeler, E ; Carrasco-Zanini, J ; et al.

Schlagworte: ABO Blood-Group System; Aptamers; Peptide; Blood Coagulation; COVID-19; Drug Delivery Systems; Female; Gene Expression Regulation; Host-Derived Cellular Factors; Host-Pathogen Interactions; Humans; Internet; Male; Middle Aged; Proteins; Quantitative Trait Loci; SARS-CoV-2
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12
Genetic architecture of host proteins involved in SARS-CoV-2 infection

von Pietzner, M ; Wheeler, E ; Carrasco-Zanini, J ; et al.

Nature Communications , 11 , Article 6397. (2020)

Schlagworte: ABO Blood-Group System; Aptamers; Peptide; Blood Coagulation; COVID-19; Drug Delivery Systems; Female; Gene Expression Regulation; Host-Derived Cellular Factors; Host-Pathogen Interactions; Humans; Internet; Male; Middle Aged; Proteins; Quantitative Trait Loci; SARS-CoV-2
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13
A multi-ancestry genome-wide study incorporating gene–smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure

von Sung, YJ ; de las Fuentes, L ; Winkler, TW ; et al.
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14
Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits

von Kraja AT ; Liu C ; Fetterman JL ; et al.

American Journal of Human Genetics, 3 January 2019
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15
Associations of autozygosity with a broad range of human phenotypes

von Clark DW ; Okada Y ; Moore KHS ; et al.
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16
Associations of autozygosity with a broad range of human phenotypes

von Clark, David W. ; Cocca, M ; Collins, FS ; et al.

Schlagworte: autozygosity; human phenotypes; quantitiative traits; enotyping
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17
Circulating fetuin-A and risk of type 2 diabetes: a mendelian randomization analysis

von Kröger, J ; Meidtner, K ; Stefan, N ; et al.
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18
Associations of autozygosity with a broad range of human phenotypes

von Clark, DW ; Okada, Y ; Moore, KHS ; et al.

Nature Communications , 10 , Article 4957. (2019)
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19
A large-scale multi-ancestry genome-wide study accounting for smoking behavior identifies multiple significant loci for blood pressure

von Sung, YJ ; Winkler, TW ; de Las Fuentes, L ; et al.
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20
Association of genetically enhanced lipoprotein lipase–mediated lipolysis and low-density lipoprotein cholesterol–lowering alleles with risk of coronary disease and type 2 diabetes

von Lotta, LA ; Stewart, ID ; Sharp, SJ ; et al.
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21
Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility

von Wessel, J ; Chu, AY ; Willems, SM ; et al.
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22
An expanded genome-wide association study of type 2 diabetes in Europeans

von Scott, RA ; Scott, LJ ; Mägi, R ; et al.
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23
Proteogenomic links to human metabolic diseases

von Koprulu, M ; Carrasco-Zanini, J ; Wheeler, E ; et al.
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24
Genetic predisposition to mosaic Y chromosome loss in blood.

von Thompson, DJ ; Genovese, G ; Halvardson, J ; et al.

Schlagworte: Adult; Aged; Chromosome Deletion; Chromosomes; Human; Computational Biology; Databases; Genetic; Female; Genetic Markers; Genetic Predisposition to Disease; Genomic Instability; Humans; Leukocytes; Male; Middle Aged; Mosaicism; Neoplasms; United Kingdom
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25
A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease

von Scott, RA ; Freitag, DF ; Li, L ; et al.

Science Translational Medicine , 8 (341) , Article 341ra76. (2016)
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