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1
Defactinib with avutometinib in patients with solid tumors: the phase 1 FRAME trial

von Banerjee, Susana ; Krebs, Matthew G. ; Greystoke, Alastair ; et al.

Nature Medicine. 31(9):3074-3080
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2
DECOVID: A UK Two-Center Harmonized Database of Acute Care Electronic Health Records for COVID-19 Research

von DECOVID Consortium ; Louis J. M. Aslett ; Andreea Avramescu ; et al.

Data, Vol 10, Iss 12, p 195 (2025)

Schlagworte: hospital data; electronic health record; COVID-19; Bibliography. Library science. Information resources
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3
GABAergic neuronal lineage development determines clinically actionable targets in diffuse hemispheric glioma, H3G34-mutant

von Liu, Ilon ; Alencastro Veiga Cruzeiro, Gustavo ; Bjerke, Lynn ; et al.

In Cancer Cell 9 September 2024 42(9):1528-1548
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4
Targeting myeloid chemotaxis to reverse prostate cancer therapy resistance

von Guo, Christina ; Sharp, Adam ; Gurel, Bora ; et al.

Nature: International weekly journal of science. 623(7989):1053-1061
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5
DIPG-22. A NOVEL ROLE FOR ACVR1/ALK2 IN REGULATING CHOLESTEROL BIOSYNTHESIS PROVIDES A NEW COMBINATORIAL THERAPEUTIC APPROACH FOR PATIENTS WITH DMG

von Rogers, Rebecca ; Grabovaska, Yura ; Mackay, Alan ; et al.

Neuro-Oncology ; volume 26, issue Supplement_4, page 0-0 ; ISSN 1522-8517 1523-5866
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6
A Phase I Trial of CT900, a Novel α-Folate Receptor-Mediated Thymidylate Synthase Inhibitor, in Patients with Solid Tumors with Expansion Cohorts in Patients with High-Grade Serous Ovarian Cancer.

von Banerjee, Susana ; Michalarea, Vasiliki ; Ang, Joo Ern ; et al.

Schlagworte: Humans; Female; Thymidylate Synthase; Maximum Tolerated Dose; Neoplasms; Enzyme Inhibitors; Ovarian Neoplasms; Folic Acid
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7
Discovery of 4-Amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides As Selective, Orally Active Inhibitors of Protein Kinase B (Akt)

von McHardy, Tatiana ; Caldwell, John J. ; Cheung, Kwai-Ming ; et al.

Journal of Medicinal Chemistry. 53(5):2239-2249
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8
DIPG-29. A CONNECT CONSORTIUM PRECLINICAL STUDY IDENTIFIES MEK INHIBITION AND RADIATION AS POTENTIAL COMBINATION PARTNERS FOR THE ALK2 INHIBITOR TP-0184 IN ACVR1-MUTANT DMG

von Rogers, Rebecca ; Tsoli, Maria ; Kumar, Shiva Senthil ; et al.

Neuro-Oncology ; volume 25, issue Supplement_1, page i19-i19 ; ISSN 1522-8517 1523-5866
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9
A Phase I Trial of CT900, a Novel a-Folate Receptor–Mediated Thymidylate Synthase Inhibitor, in Patients with Solid Tumors with Expansion Cohorts in Patients with High-Grade Serous Ovarian Cancer

von Banerjee, Susana ; Michalarea, Vasiliki ; Ang, Joo Ern ; et al.

Banerjee, S, Michalarea, V, Ang, J E, Garces, A I, Biondo, A, Funingana, I G, Little, M, Ruddle, R, Raynaud, F, Riisnaes, R, Gurel, B, Chua, S, Tunariu, N, Porter, J C, Prout, T, Parmar, M, Zachariou, A, Turner, A, Jenkins, B, McIntosh, S, Ainscow, E, Minchom, A, Lopez, J, de Bono, J, Jones, R, Hall, E, Cook, N, Basu, B & Banerji, U 2022, 'A Phase I Trial of CT900, a Novel a-Folate Receptor–Mediated Thymidylate Synthase Inhibitor, in Patients with Solid Tumors with Expansion Cohorts in Patients with High-Grade Serous Ovarian Cancer', Clinical Cancer Research, vol. 28, no. ....

Schlagworte: ResearchInstitutes_Networks_Beacons/mcrc; name=Manchester Cancer Research Centre
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10
A phase I trial of CT900, a novel α-folate receptor-mediated thymidylate synthase inhibitor, with expansion cohorts in patients with high grade serous ovarian cancer

von Banerjee, Susana ; Michalarea, Vasiliki ; Ang, Joo Ern ; et al.

Clinical Cancer Research (2022) (In press).
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11
EXTH-93. Combination of ALK2 and cholesterol targeting agents exploits linked genetic and metabolic dependencies in diffuse midline glioma

von Rogers, Rebecca ; Grabovska, Yura ; Mackay, Alan ; et al.

Neuro-Oncology ; volume 27, issue Supplement_5, page v361-v361 ; ISSN 1522-8517 1523-5866
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12
Metabolomic changes of the multi (-AGC-) kinase inhibitor AT13148 in cells, mice and patients are associated with NOS regulation

von Pal, Akos ; Asad, Yasmin ; Ruddle, Ruth ; et al.
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13
EXTH-46. ARTIFICIAL INTELLIGENCE-BASED IDENTIFICATION OF COMBINED VANDETANIB AND EVEROLIMUS IN THE TREATMENT OF ACVR1-MUTANT DIFFUSE INTRINSIC PONTINE GLIOMA

von Carvalho, Diana ; Richardson, Peter ; Olaciregui, Nagore Gene ; et al.

Neuro-Oncology ; volume 22, issue Supplement_2, page ii97-ii97 ; ISSN 1522-8517 1523-5866
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14
Combined MYC and P53 Defects Emerge at Medulloblastoma Relapse and Define Rapidly Progressive, Therapeutically Targetable Disease

von Hill, Rebecca M. ; Kuijper, Sanne ; Lindsey, Janet C. ; et al.

In Cancer Cell 12 January 2015 27(1):72-84
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15
ALK2 inhibitors display beneficial effects in preclinical models of ACVR1 mutant diffuse intrinsic pontine glioma

von Carvalho, Diana ; Taylor, Kathryn R. ; Olaciregui, Nagore Gene ; et al.

Communications Biology ; volume 2, issue 1 ; ISSN 2399-3642
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16
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von Banerjee, Susana ; Michalarea, Vasiliki ; Ang, Joo Ern ; et al.

Schlagworte: Humans; Female; Thymidylate Synthase; Maximum Tolerated Dose; Neoplasms; Enzyme Inhibitors; Ovarian Neoplasms; Folic Acid; Article
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17
FRAME: A phase I trial of defactinib (FAK inhibitor) in combination with avutometinib (RAF-MEK clamp) in patients with solid tumours including low grade serous ovarian cancer

von Banerji, Udai ; Banerjee, Susana ; Krebs, Matthew ; et al.
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18
Correction to: An in vitro and in vivo study of the combination of the heat shock protein inhibitor 17-allylamino-17-demethoxygeldanamycin and carboplatin in human ovarian cancer models

von Banerji, Udai ; Sain, Nivedita ; Sharp, Swee Y. ; et al.

Cancer Chemotherapy and Pharmacology ; volume 82, issue 5, page 911-912 ; ISSN 0344-5704 1432-0843
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19
DIPG-29. PRECLINICAL EFFICACY OF COMBINED ACVR1 AND PI3K/mTOR INHIBITION IN DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG)

von Carvalho, Diana ; Olaciregui, Nagore Gene ; Ruddle, Ruth ; et al.

Neuro-Oncology ; volume 20, issue suppl_2, page i54-i55 ; ISSN 1522-8517 1523-5866
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20
Identification of 4-(4-Aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as Selective Inhibitors of Protein Kinase B through Fragment Elaboration; Selective Inhibitors of Protein Kinase B

von Caldwell, John J. ; Davies, Thomas G. ; Donald, Alastair ; et al.

Journal of Medicinal Chemistry. 51(7):2147-2157
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21
HG-67PRECLINICAL EFFICACY OF ALK2 INHIBITORS IN ACVR1 MUTANT DIPG

von Carvalho, Diana ; Taylor, Kathryn ; Olaciregui, Nagore G. ; et al.

Neuro-Oncology ; volume 18, issue suppl 3, page iii63.1-iii63 ; ISSN 1522-8517 1523-5866
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22
PDTB-20. PRECLINICAL EFFICACY OF ALK2 INHIBITORS IN ACVR1 MUTANT DIPG

von Carvalho, Diana ; Taylor, Kathryn ; Olaciregui, Nagore Gene ; et al.

Neuro-Oncology ; volume 18, issue suppl_6, page vi154-vi154 ; ISSN 1522-8517 1523-5866
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23
Repurposing Vandetanib plus Everolimus for the Treatment of ACVR1 -Mutant Diffuse Intrinsic Pontine Glioma

von Carvalho, Diana ; Richardson, Peter ; Olaciregui, Nagore ; et al.

EISSN: 2159-8290 ; Cancer Discovery ; https://hal.science/hal-04493161 ; Cancer Discovery, 2022, 12 (2), pp.416-431. ⟨10.1158/2159-8290.CD-20-1201⟩

Schlagworte: [SDV]Life Sciences [q-bio]
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24
An in vitro and in vivo study of the combination of the heat shock protein inhibitor 17-allylamino-17-demethoxygeldanamycin and carboplatin in human ovarian cancer models

von Banerji, Udai ; Sain, Nivedita ; Sharp, Swee Y. ; et al.

Cancer Chemotherapy and Pharmacology. 62(5):769-778
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25
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