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Treffer 1 - 25 von 448, Suchdauer: 0.91s

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1
On electrostatic interactions of adenosine triphosphate–insulin‐degrading enzyme revealed by quantum mechanics/molecular mechanics and molecular dynamics

von Sarawoot Somin ; Don Kulasiri ; Sandhya Samarasinghe

Quantitative Biology, Vol 12, Iss 4, Pp 414-432 (2024)

Schlagworte: electrostatic interactions; molecular dynamic simulation; QM/MM calculation method; thermostability/flexibility; Biology (General); QH301-705.5; Biotechnology; TP248.13-248.65
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2
Alleviating the unwanted effects of oxidative stress on Aβ clearance: a review of related concepts and strategies for the development of computational modelling

von Sarawoot Somin ; Don Kulasiri ; Sandhya Samarasinghe

Translational Neurodegeneration, Vol 12, Iss 1, Pp 1-20 (2023)

Schlagworte: Alzheimer’s disease; Oxidative stress; Amyloid beta clearance; Protein design; Neurology. Diseases of the nervous system; RC346-429
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3
Fundamental Boolean network modelling for childhood acute lymphoblastic leukaemia pathways

von Leshi Chen ; Don Kulasiri ; Sandhya Samarasinghe

Quantitative Biology, Vol 10, Iss 1, Pp 94-121 (2022)

Schlagworte: Boolean modelling; Boolean network; time series data; network inference; data‐driven boolean modelling; fundamental boolean model; Biology (General); QH301-705.5; Biotechnology; TP248.13-248.65
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4
Modeling protein-protein interactions in axon initial segment to understand their potential impact on action potential initiation

von Piyush Bhardwaj ; Don Kulasiri ; Sandhya Samarasinghe

Neural Regeneration Research, Vol 16, Iss 4, Pp 700-706 (2021)

Schlagworte: alzheimer’s disease; ankyrin-g; axon initial segment; casein kinase-2; microtubules; voltage-gated potassium channel; voltage-gated sodium channel; Neurology. Diseases of the nervous system; RC346-429
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5
Functional repertoire of protein kinases and phosphatases in synaptic plasticity and associated neurological disorders

von Raheel Khan ; Don Kulasiri ; Sandhya Samarasinghe

Neural Regeneration Research, Vol 16, Iss 6, Pp 1150-1157 (2021)

Schlagworte: alzheimer’s disease; autism spectrum disorder; camkii; calcineurin; long-term depression; long-term potentiation; protein kinase a; protein phosphatase 1; protein dephosphorylation; protein phosphorylation; Neurology. Diseases of the nervous system; RC346-429
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6
Novel domain expansion methods to improve the computational efficiency of the Chemical Master Equation solution for large biological networks

von Rahul Kosarwal ; Don Kulasiri ; Sandhya Samarasinghe

BMC Bioinformatics, Vol 21, Iss 1, Pp 1-42 (2020)

Schlagworte: Biochemical reaction networks; chemical master equation; stochastic; intelligent state projection; Bayesian likelihood node projection; Computer applications to medicine. Medical informatics; R858-859.7; Biology (General); QH301-705.5
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7
Computational Modelling of Synaptic Plasticity: A review of models, parameter estimation using deep learning, and stochasticity

von Kumarapathirana, K. P. S. D. ; Kulasiri, Don ; Samarasinghe, Sandhya ; et al.

2021 6th International Conference on Information Technology Research (ICITR) Information Technology Research (ICITR), 2021 6th International Conference on. :1-7 Dec, 2021
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8
Neurons and neural networks to model proteins and protein networks

von Samarasinghe, Sandhya ; Minh-Thai, Tran Nguyen ; Sorthiya, Komal ; et al.

In BioSystems December 2025 258
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9
A Modeling and Analysis Study Reveals That CaMKII in Synaptic Plasticity Is a Dominant Affecter in CaM Systems in a T286 Phosphorylation-Dependent Manner

von Hamish Stevens-Bullmore ; Don Kulasiri ; Sandhya Samarasinghe

Molecules, Vol 27, Iss 18, p 5974 (2022)

Schlagworte: Ca2+ signaling; calmodulin; calmodulin-dependent kinase II; protein phosphatase 1; cell signaling; mathematical model; Organic chemistry; QD241-441
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10
End-to-End Knowledge Graph Construction System Powered by Large Language Models

von Pang, Zijian ; Samarasinghe, Sandhya ; Kumarapathirana, Samantha ; et al.

Neural Information Processing : 31st International Conference, ICONIP 2024, Auckland, New Zealand, December 2–6, 2024, Proceedings, Part XII. 2293:17-30
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11
Modelling Socio-ecological Systems: Implementation of an Advanced Fuzzy Cognitive Map Framework for Policy development for addressing complex real-life challenges

von Obiedat, Mamoon ; Samarasinghe, Sandhya

Schlagworte: Computer Science - Social and Information Networks; J.2
- View full text via Arxiv
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12
A Novel Data-Driven Boolean Model for Genetic Regulatory Networks

von Leshi Chen ; Don Kulasiri ; Sandhya Samarasinghe

Frontiers in Physiology, Vol 9 (2018)

Schlagworte: boolean modeling; boolean network; time series data; network inference; data-driven boolean modeling; fundamental boolean model; Physiology; QP1-981
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13
Computational investigation of Amyloid-β-induced location- and subunit-specific disturbances of NMDAR at hippocampal dendritic spine in Alzheimer's disease.

von Jingyi Liang ; Don Kulasiri ; Sandhya Samarasinghe

PLoS ONE, Vol 12, Iss 8, p e0182743 (2017)

Schlagworte: Medicine; Science
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14
Proteins as fuzzy controllers: Auto tuning a biological fuzzy inference system to predict protein dynamics in complex biological networks

von Alsharaiah, Mohammad Abdallah ; Samarasinghe, Sandhya ; Kulasiri, Don

In BioSystems February 2023 224
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15
Collective computational intelligence in biology – Emergence of memory in somatic tissues

von Samarasinghe, Sandhya

In BioSystems January 2023 223
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16
Robustness of CDK2 in triggering cellular senescence based on probability of DNA-damaged cells passing G1/S checkpoint

von Ling, Hong ; Samarasinghe, Sandhya ; Kulasiri, Don

2011 IEEE International Conference on Systems Biology (ISB) Systems Biology (ISB), 2011 IEEE International Conference on. :1-7 Sep, 2011
- Zum Volltext in IEEE Xplore
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17
3D QSAR and pharmacophore studies on inhibitors of insuline like growth factor 1 receptor (IGF-1R) and insulin receptor (IR) as potential anti-cancer agents

von Pasha, Mustafa Kamal ; Jabeen, Ishrat ; Samarasinghe, Sandhya

In Current Research in Chemical Biology 2022 2
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18
Improving Water Distribution in a Multi-Agent System Using Fixed Multiunit First-Price Sealed-Bid Auction

von Chiewchan, Kitti ; Anthony, Patricia ; Birendra, K. C. ; et al.

Agents and Multi-Agent Systems: Technologies and Applications 2021 : Proceedings of 15th KES International Conference, KES-AMSTA 2021, June 2021. 241:465-475
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19
A new hierarchical approach to multi-level model abstraction for simplifying ODE models of biological networks and a case study: The G1/S Checkpoint/DNA damage signalling pathways of mammalian cell cycle

von Khazaaleh, Mutaz ; Samarasinghe, Sandhya ; Kulasiri, Don

In BioSystems May 2021 203
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20
Improving Water Allocation Using Multi-agent Negotiation Mechanisms

von Chiewchan, Kitti ; Anthony, Patricia ; Birendra, K. C. ; et al.

Agents and Multi-agent Systems: Technologies and Applications 2019 : 13th KES International Conference, KES-AMSTA-2019 St. Julians, Malta, June 2019 Proceedings. 148:105-115
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21
Towards abstraction of computational modelling of mammalian cell cycle: Model reduction pipeline incorporating multi-level hybrid petri nets

von Abroudi, Ali ; Samarasinghe, Sandhya ; Kulasiri, Don

In Journal of Theoretical Biology 7 July 2020 496
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22
Using activity time windows and logical representation to reduce the complexity of biological network models: G1/S checkpoint pathway with DNA damage

von Khazaaleh, Mutaz ; Samarasinghe, Sandhya

In BioSystems May 2020 191-192
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23
Agent Based Irrigation Management for Mixed-Cropping Farms

von Chiewchan, Kitti ; Anthony, Patricia ; Samarasinghe, Sandhya ; et al.

Computational Science and Technology : 5th ICCST 2018, Kota Kinabalu, Malaysia, 29-30 August 2018. 481:471-480
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24
Mathematical modelling of core regulatory mechanism in p53 protein that activates apoptotic switch

von Chong, Ket Hing ; Samarasinghe, Sandhya ; Kulasiri, Don ; et al.

In Journal of Theoretical Biology 7 February 2019 462:134-147
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25
Stochastic Neural Networks for Modelling Random Processes from Observed Data

von Ling, Hong ; Samarasinghe, Sandhya ; Kulasiri, Don ; et al.

Artificial Neural Network Modelling. 628:83-107
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