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Treffer 1 - 25 von 236, Suchdauer: 0.77s

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1
HSF1 Pathway Inhibitor Clinical Candidate (CCT361814/NXP800) Developed from a Phenotypic Screen as a Potential Treatment for Refractory Ovarian Cancer and Other Malignancies

von Pasqua, A. Elisa ; Sharp, Swee Y. ; Chessum, Nicola E. A. ; et al.

Journal of Medicinal Chemistry. 66(8):5907-5936
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2
Integrating fragment-based screening with targeted protein degradation and genetic rescue to explore eIF4E function

von Sharp, Swee Y. ; Martella, Marianna ; D’Agostino, Sabrina ; et al.

Nature Communications. 15(1)
- Zum Volltext in PubMed Central
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3
Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766)

von Chessum, Nicola E. A. ; Sharp, Swee Y. ; Caldwell, John J. ; et al.

Journal of Medicinal Chemistry. 61(3):918-933
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4
Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen

von Cheeseman, Matthew D. ; Chessum, Nicola E. A. ; Rye, Carl S. ; et al.

Journal of Medicinal Chemistry. 60(1):180-201
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5
Targeting the Hsp90 Molecular Chaperone with Novel Macrolactams. Synthesis, Structural, Binding, and Cellular Studies

von Day, James E. H. ; Sharp, Swee Y. ; Rowlands, Martin G. ; et al.

ACS Chemical Biology. 6(12):1339-1347
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6
Combining Hit Identification Strategies: Fragment-Based and in Silico Approaches to Orally Active 2-Aminothieno[2,3-d]pyrimidine Inhibitors of the Hsp90 Molecular Chaperone

von Brough, Paul A. ; Barril, Xavier ; Borgognoni, Jenifer ; et al.

Journal of Medicinal Chemistry. 52(15):4794-4809
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7
Solution structure of the Hop TPR2A domain and investigation of target druggability by NMR, biochemical and in silico approaches

von Darby, John F. ; Vidler, Lewis R. ; Simpson, Peter J. ; et al.

Scientific Reports. 10(1)
- Zum Volltext in PubMed Central
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8
Cervical Cancer

von Sharp, Swee Y. ; Kelland, Lloyd R. ; Masters, John R. W., editor ; et al.

Human Cell Culture : Cancer Cell Lines Part 2. 2:55-70
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9
Correction to: An in vitro and in vivo study of the combination of the heat shock protein inhibitor 17-allylamino-17-demethoxygeldanamycin and carboplatin in human ovarian cancer models

von Banerji, Udai ; Sain, Nivedita ; Sharp, Swee Y. ; et al.

Cancer Chemotherapy and Pharmacology ; volume 82, issue 5, page 911-912 ; ISSN 0344-5704 1432-0843
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10
4,5-Diarylisoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer; Hsp90 Inhibitors

von Brough, Paul A. ; Aherne, Wynne ; Barril, Xavier ; et al.

Journal of Medicinal Chemistry. 51(2):196-218
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11
Discovery of 4,6-disubstituted pyrimidines as potent inhibitors of the heat shock factor 1 (HSF1) stress pathway and CDK9

von Rye, Carl S. ; Chessum, Nicola E. A. ; Lamont, Scott ; et al.

MedChemComm ; volume 7, issue 8, page 1580-1586 ; ISSN 2040-2503 2040-2511
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12
Correction: Discovery of 4,6-disubstituted pyrimidines as potent inhibitors of the heat shock factor 1 (HSF1) stress pathway and CDK9. See DOI: 10.1039/c6md00159a

von Rye, Carl S. ; Chessum, Nicola E. A. ; Lamont, Scott ; et al.

MedChemComm ; volume 7, issue 9, page 1870-1870 ; ISSN 2040-2503 2040-2511
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13
An in vitro and in vivo study of the combination of the heat shock protein inhibitor 17-allylamino-17-demethoxygeldanamycin and carboplatin in human ovarian cancer models

von Banerji, Udai ; Sain, Nivedita ; Sharp, Swee Y. ; et al.

Cancer Chemotherapy and Pharmacology. 62(5):769-778
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14
Co-crystalization and in vitro biological characterization of 5-Aryl-4-(5-substituted-2-4-dihydroxyphenyl)-1,2,3-thiadiazole Hsp90 inhibitors

von Sharp, Swee Y ; Roe, S Mark ; Kazlauskas, Egidijus ; et al.

Schlagworte: Q Science; R Medicine
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15
Heat shock protein inhibition is associated with activation of the unfolded protein response pathway in myeloma plasma cells

von Davenport, Emma L. ; Moore, Hannah E. ; Dunlop, Alan S. ; et al.

In Blood 1 October 2007 110(7):2641-2649
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16
Effects of HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG) on NEU/HER2 overexpressing mammary tumours in MMTV-NEU-NT mice monitored by Magnetic Resonance Spectroscopy

von Rodrigues Loreta M ; Chung Yuen-Li ; Al Saffar Nada M S ; et al.

BMC Research Notes, Vol 5, Iss 1, p 250 (2012)

Schlagworte: Magnetic resonance spectroscopy; MMTV-NEU-NT tumours; ERBB2/ HER2/ NEU; HSP90; 17-AAG; Medicine; Biology (General); QH301-705.5; Science (General); Q1-390
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17
Effects of HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG) on NEU/HER2 overexpressing mammary tumours in MMTV-NEU-NT mice monitored by Magnetic Resonance Spectroscopy

von Rodrigues, Loreta M ; Chung, Yuen-Li ; Al Saffar, Nada M S ; et al.

Schlagworte: Magnetic resonance spectroscopy; MMTV-NEU-NT tumours; ERBB2/ HER2/ NEU; HSP90; 17-AAG
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18
MGMT-independent temozolomide resistance in pediatric glioblastoma cells associated with a PI3-kinase-mediated HOX/stem cell gene signature

von Gaspar, Nathalie ; Marshall, Lynley ; Perryman, Lara ; et al.

Schlagworte: Antineoplastic Agents; Alkylating; Blotting; Western; Cell Line; Tumor; Cell Proliferation; Cell Survival; Child; Cluster Analysis; DNA Methylation; Dacarbazine; Drug Resistance; Neoplasm; Flow Cytometry; Gene Expression Profiling; Gene Expression Regulation; Neoplastic; Glioblastoma; Homeobox A10 Proteins; Homeodomain Proteins; Humans; Inhibitory Concentration 50; Neoplastic Stem Cells; O(6)-Methylguanine-DNA Methyltransferase; Oligonucleotide Array Sequence Analysis; Phosphatidylinositol 3-Kinases; Promoter Regions; Genetic; Temozolomide
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19
EGFRvIII deletion mutations in pediatric high-grade glioma and response to targeted therapy in pediatric glioma cell lines

von Bax, Dorine A. ; Gaspar, Nathalie ; Little, Suzanne E. ; et al.

Schlagworte: Adolescent; Blotting; Western; Cell Proliferation; Child; ErbB Receptors; Erlotinib Hydrochloride; Glioma; Humans; Prognosis; Quinazolines; Retrospective Studies; Reverse Transcriptase Polymerase Chain Reaction; Sensitivity and Specificity; Tumor Cells; Cultured; Sequence Deletion; Science & Technology
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20
Inhibition of Hsp90 with Synthetic Macrolactones: Synthesis and Structural and Biological Evaluation of Ring and Conformational Analogs of Radicicol

von Proisy, Nicolas ; Sharp, Swee Y. ; Boxall, Kathy ; et al.

Chemistry & Biology ; volume 13, issue 11, page 1203-1215 ; ISSN 1074-5521
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21
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22
DT-Diaphorase Expression and Tumor Cell Sensitivity to 17-Allylamino,17-demethoxygeldanamycin, an Inhibitor of Heat Shock Protein 90

von Kelland, Lloyd R. ; Sharp, Swee Y. ; Rogers, Paul M. ; et al.

Schlagworte: ARTICLES
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23
Co-crystalization and in vitro biological characterization of 5-aryl-4-(5-substituted-2-4-dihydroxyphenyl)-1,2,3-thiadiazole Hsp90 inhibitors.

von Swee Y Sharp ; S Mark Roe ; Egidijus Kazlauskas ; et al.

PLoS ONE, Vol 7, Iss 9, p e44642 (2012)

Schlagworte: Medicine; Science
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24
Correction: In vitro Biological Characterization of a Novel, Synthetic Diaryl Pyrazole Resorcinol Class of Heat Shock Protein 90 Inhibitors

von Sharp, Swee Y ; Boxall, Kathy ; Rowlands, Martin ; et al.
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25
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