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1
DMPK Considerations for the Development of Covalent Drugs: Insights from an IQ Assessment

von Dopstadt, Julian ; Behnia, Kamelia ; Cui, Xiaoming ; et al.

Journal of Medicinal Chemistry. 69(9):9891-9907
- View full text at ACS Publications
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2
Discovery and In Vivo Exploration of 1,3,4-Oxadiazole and α‑Fluoroacrylate Containing IL-17 Inhibitors

von Velcicky, Juraj ; Bauer, Matthias R. ; Schlapbach, Achim ; et al.

Journal of Medicinal Chemistry. 67(18):16692-16711
- View full text at ACS Publications
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3
Predicting the Intravenous Pharmacokinetics of Covalent Drugs in Animals and Humans

von Stringer, Rowan ; Kaster, Tobias

Journal of Medicinal Chemistry. 67(15):12807-12818
- View full text at ACS Publications
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4
JDQ443, a Structurally Novel, Pyrazole-Based, Covalent Inhibitor of KRASG12C for the Treatment of Solid Tumors

von Lorthiois, Edwige ; Gerspacher, Marc ; Beyer, Kim S. ; et al.

Journal of Medicinal Chemistry. 65(24):16173-16203
- View full text at ACS Publications
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5
Discovery and Optimization of Novel SUCNR1 Inhibitors: Design of Zwitterionic Derivatives with a Salt Bridge for the Improvement of Oral Exposure

von Velcicky, Juraj ; Wilcken, Rainer ; Cotesta, Simona ; et al.

Journal of Medicinal Chemistry. 63(17):9856-9875
- View full text at ACS Publications
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6
Higher dose corticosteroids in hospitalised COVID-19 patients requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trialResearch in context

von O. Abani ; A. Abbas ; F. Abbas ; et al.

EClinicalMedicine, Vol 81, Iss , Pp 103080- (2025)

Schlagworte: COVID-19; Corticosteroid; Dexamethasone; Mortality; Clinical trial; Medicine (General); R5-920
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7
Structure-Based and Property-Driven Optimization of N‑Aryl Imidazoles toward Potent and Selective Oral RORγt Inhibitors

von Hoegenauer, Klemens ; Kallen, Joerg ; Jiménez-Núñez, Eloísa ; et al.

Journal of Medicinal Chemistry. 62(23):10816-10832
- View full text at ACS Publications
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8
Optimizing a Weakly Binding Fragment into a Potent RORγt Inverse Agonist with Efficacy in an in Vivo Inflammation Model

von Carcache, David A. ; Vulpetti, Anna ; Kallen, Joerg ; et al.

Journal of Medicinal Chemistry. 61(15):6724-6735
- View full text at ACS Publications
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9
Use of term reference infants in assessing the developmental outcome of extremely preterm infants: lessons learned in a multicenter study

von Green, Charles E. ; Tyson, Jon E. ; Heyne, Roy J. ; et al.

Journal of Perinatology. 43(11):1398-1405
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10
Optimization of Platelet-Derived Growth Factor Receptor (PDGFR) Inhibitors for Duration of Action, as an Inhaled Therapy for Lung Remodeling in Pulmonary Arterial Hypertension

von Shaw, Duncan E. ; Baig, Ferheen ; Bruce, Ian ; et al.

Journal of Medicinal Chemistry. 59(17):7901-7914
- View full text at ACS Publications
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11
Discovery, Optimization, and Biological Evaluation of 5‑(2-(Trifluoromethyl)phenyl)indazoles as a Novel Class of Transient Receptor Potential A1 (TRPA1) Antagonists

von Rooney, Lisa ; Vidal, Agnès ; D’Souza, Anne-Marie ; et al.

Journal of Medicinal Chemistry. 57(12):5129-5140
- View full text at ACS Publications
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12
Clearance Mechanism Assignment and Total Clearance Prediction in Human Based upon in Silico Models

von Lombardo, Franco ; Obach, R. Scott ; Varma, Manthena V. ; et al.

Journal of Medicinal Chemistry. 57(10):4397-4405
- View full text at ACS Publications
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13
Tropifexor plus cenicriviroc combination versus monotherapy in nonalcoholic steatohepatitis : results from the phase 2b TANDEM study

von Anstee, Quentin M. ; Lucas, Kathryn J. ; Francque, Sven ; et al.

0270-9139 ; Hepatology

Schlagworte: Human medicine
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14
Pharmacokinetics of Tropifexor, a Potent Farnesoid X Receptor Agonist, in Participants With Varying Degrees of Hepatic Impairment

von Chen, Jin ; Gu, Jessie ; Shah, Bharti ; et al.

The Journal of Clinical Pharmacology ; volume 62, issue 4, page 520-531 ; ISSN 0091-2700 1552-4604
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15
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- Zur Referenz in Web of Science
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16
Discovery of Fevipiprant (NVP-QAW039), a Potent and Selective DP2 Receptor Antagonist for Treatment of Asthma

von Sandham, David A. ; Barker, Lucy ; Brown, Lyndon ; et al.

ACS Medicinal Chemistry Letters. 8(5):582-586
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17
1-Aminobenzotriazole Modulates Oral Drug Pharmacokinetics through Cytochrome P450 Inhibition and Delay of Gastric Emptying in Rats

von Stringer, Rowan A. ; Weber, Eckhard ; Tigani, Bruno ; et al.

In Drug Metabolism and Disposition July 2014 42(7):1117-1124
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18
Application of a Deuterium Replacement Strategy to Modulate the Pharmacokinetics of 7-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-3-(4-methoxy-2-methylphenyl)-2,6-dimethylpyrazolo[5,1-b]oxazole, a Novel CRF1 Antagonist

von Stringer, Rowan A. ; Williams, Gareth ; Picard, Franck ; et al.

In Drug Metabolism and Disposition May 2014 42(5):954-962
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19
Discovery and characterization of NVP-QAV680, a potent and selective CRTh2 receptor antagonist suitable for clinical testing in allergic diseases

von Sandham, David A. ; Arnold, Nicola ; Aschauer, Heinrich ; et al.

In Bioorganic & Medicinal Chemistry 1 November 2013 21(21):6582-6591
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20
Transient targeting of phosphoinositide 3-kinase acts as a roadblock in mast cells' route to allergy

von Collmann, Emilie ; Bohnacker, Thomas ; Marone, Romina ; et al.

In The Journal of Allergy and Clinical Immunology October 2013 132(4):959-968
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21
Utility of food pellets containing 1-aminobenzotriazole for longer termin vivoinhibition of cytochrome P450 in mice

von Stringer, Rowan ; Cordier, Valerie ; Afatsawo, Catherine ; et al.

Xenobiotica ; volume 49, issue 1, page 13-21 ; ISSN 0049-8254 1366-5928
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22
Correction to “Discovery of Fevipiprant (NVP-QAW039), a Potent and Selective DP 2 Receptor Antagonist for Treatment of Asthma”

von Sandham, David A. ; Barker, Lucy ; Brown, Lyndon ; et al.

ACS Medicinal Chemistry Letters ; volume 8, issue 9, page 987-987 ; ISSN 1948-5875 1948-5875
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23
Tropifexor plus cenicriviroc combination versus monotherapy in nonalcoholic steatohepatitis: Results from the phase 2b TANDEM study.

von Anstee, Quentin ; Anstee, Quentin ; Lucas, Kathryn ; et al.

Hepatology; vol 78, iss 4

Schlagworte: Humans; Non-alcoholic Fatty Liver Disease; Double-Blind Method; Treatment Outcome; Fibrosis; Body Weight; article
- Zum Volltext über OAIster
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24
A Study to Evaluate Relative Bioavailability, Food Effect, and Pharmacodynamics of Tropifexor, a Farnesoid X Receptor Agonist, in Healthy Participants.

von Stringer, Rowan ; Chen, Jin ; Shah, Bharti ; et al.
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25
Application of Osmotic Pumps for Sustained Release of 1-Aminobenzotriazole and Inhibition of Cytochrome P450 Enzymes in Mice: Model Comparison with the Hepatic P450 Reductase Null Mouse

von Stringer, Rowan A. ; Ferreira, Suzie ; Rose, Jonathan ; et al.

Drug Metabolism and Disposition ; volume 44, issue 8, page 1213-1216 ; ISSN 0090-9556
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