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1
Impact of antibody Fc engineering on translational pharmacology, and safety: insights from industry case studies

von Frank R. Brennan ; J. Ryan Polli ; Jean Sathish ; et al.

mAbs, Vol 17, Iss 1 (2025)

Schlagworte: Effector function; Fc enhancement; Fc receptor blockade; Fc receptors; Fc silencing; monoclonal antibody; Therapeutics. Pharmacology; RM1-950; Immunologic diseases. Allergy; RC581-607
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2
Oral paltusotine, a nonpeptide selective somatostatin receptor 2 agonist: Mass balance, absolute bioavailability and metabolism in healthy participants

von Luo, Rosa ; Madan, Ajay ; Ferrara‐Cook, Christine T. ; et al.

British Journal of Clinical Pharmacology ; volume 91, issue 7, page 2070-2079 ; ISSN 0306-5251 1365-2125
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3
Discovery of CRN04894: A Novel Potent Selective MC2R Antagonist

von Kim, Sun Hee ; Han, Sangdon ; Zhao, Jian ; et al.

ACS Medicinal Chemistry Letters. 15(4):478-485
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4
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5
An atlas of seabed biodiversity for Aotearoa New Zealand

von F. Stephenson ; T. Brough ; D. Lohrer ; et al.

Earth System Science Data, Vol 15, Pp 3931-3939 (2023)

Schlagworte: Environmental sciences; GE1-350; Geology; QE1-996.5
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6
Revival of the magnetar PSR J1622-4950: observations with MeerKAT, Parkes, XMM-Newton, Swift, Chandra, and NuSTAR

von Camilo, F. ; Scholz, P. ; Serylak, M. ; et al.

ApJ 856 (2018) 180

Schlagworte: Astrophysics - High Energy Astrophysical Phenomena
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7
Association of bradykinin receptor 2 (BDKRB2) variants with physical performance and muscle mass: Findings from the LACE sarcopenia trial.

von Alvin Shrestha ; Tufail Bashir ; Marcus Achison ; et al.

PLoS ONE, Vol 19, Iss 8, p e0307268 (2024)

Schlagworte: Medicine; Science
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8
Discovery of Paltusotine (CRN00808), a Potent, Selective, and Orally Bioavailable Non-peptide SST2 Agonist

von Zhao, Jian ; Wang, Shimiao ; Markison, Stacy ; et al.

ACS Medicinal Chemistry Letters. 14(1):66-74
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9
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10
Determinants of High-Affinity Binding and Receptor Activation in the N-Terminus of CCL-19 (MIP-3β)

von Ott, T. R. ; Lio, F. M. ; Olshefski, D. ; et al.

Biochemistry. 43(12):3670-3678
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11
Paltusotine, a novel oral once-daily nonpeptide SST2 receptor agonist, suppresses GH and IGF-1 in healthy volunteers

von Madan, Ajay ; Markison, Stacy ; Betz, Stephen F. ; et al.

Pituitary: The official publication of the Pituitary Society and the Growth Hormone Research Society. 25(2):328-339
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12
Xanthine oxidase inhibition and white matter hyperintensity progression following ischaemic stroke and transient ischaemic attack (XILO-FIST): a multicentre, double-blinded, randomised, placebo-controlled trialResearch in context

von Jesse Dawson ; Michele Robertson ; David Alexander Dickie ; et al.

EClinicalMedicine, Vol 57, Iss , Pp 101863- (2023)

Schlagworte: Stroke; Allopurinol; Hypertension; White matter hyperintensities; Medicine (General); R5-920
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13
Seeing in Circles: The Fierce Originality of The Progress of Love (1986)

von Struthers, J. R. Tim

Reading Alice Munro’s Breakthrough Books: A Suite in Four Voices. :6-50
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14
Allosteric and Orthosteric Binding Modes of Two Nonpeptide Human Gonadotropin-Releasing Hormone Receptor Antagonists

von Sullivan, Susan K. ; Brown, Michael S. ; Gao, Yinghong ; et al.

Biochemistry. 45(51):15327-15337
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15
Determination of the Binding Mode of Thienopyrimidinedione Antagonists to the Human Gonadotropin Releasing Hormone Receptor Using Structure−Activity Relationships, Site-Directed Mutagenesis, and Homology Modeling

von Betz, Stephen F. ; Lio, Francisco M. ; Gao, Yinghong ; et al.

Journal of Medicinal Chemistry. 49(21):6170-6176
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16
Activin type I receptor polymorphisms and body composition in older individuals with sarcopenia—Analyses from the LACE randomised controlled trial

von Tufail Bashir ; Marcus Achison ; Simon Adamson ; et al.

PLoS ONE, Vol 18, Iss 11 (2023)

Schlagworte: Medicine; Science
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17
ACE I/D genotype associates with strength in sarcopenic men but not with response to ACE inhibitor therapy in older adults with sarcopenia: Results from the LACE trial.

von Christos Rossios ; Tufail Bashir ; Marcus Achison ; et al.

PLoS ONE, Vol 18, Iss 10, p e0292402 (2023)

Schlagworte: Medicine; Science
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18
Overlapping, Nonidentical Binding Sites of Different Classes of Nonpeptide Antagonists for the Human Gonadotropin-Releasing Hormone Receptor

von Betz, Stephen F. ; Reinhart, Greg J. ; Lio, Francisco M. ; et al.

Journal of Medicinal Chemistry. 49(2):637-647
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19
Retrobulbar embryonal tumor with multilayered rosettes in a golden retriever dog

von Bianca C. Martins ; Jason Struthers ; Jeffrey R. Abbott ; et al.

Clinical Case Reports, Vol 9, Iss 2, Pp 660-668 (2021)

Schlagworte: dog; ETMR; neoplasia; primitive neuroectodermal tumor; Retrobulbar; tumor; Medicine; Medicine (General); R5-920
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20
3-[(2R)-Amino-2-phenylethyl]-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl)- 6-methylpyrimidin-2,4-dione (NBI 42902) as a Potent and Orally Active Antagonist of the Human Gonadotropin-Releasing Hormone Receptor. Design, Synthesis, and in Vitro and in Vivo Characterization

von Tucci, Fabio C. ; Zhu, Yun-Fei ; Struthers, R. Scott ; et al.

Journal of Medicinal Chemistry. 48(4):1169-1178
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21
Synthesis and Structure−Activity Relationships of 1-Arylmethyl-5-aryl-6-methyluracils as Potent Gonadotropin-Releasing Hormone Receptor Antagonists

von Guo, Zhiqiang ; Zhu, Yun-Fei ; Gross, Timothy D. ; et al.

Journal of Medicinal Chemistry. 47(5):1259-1271
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22
ACROBAT advance: once daily, oral paltusotine treatment maintained long-term igf-1 at levels previously achieved with injectable long-acting somatostatin receptor ligands (LA-SRLs)

von Gadelha, Monica R ; Randeva, Harpal ; Gordon, Murray B ; et al.

Endocrine Abstracts ; ISSN 1479-6848
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23
Design of Potent Dicyclic (4−10/5−8) Gonadotropin Releasing Hormone (GnRH) Antagonists

von Rivier, Jean E. ; Struthers, R. Scott ; Porter, John ; et al.

Journal of Medicinal Chemistry. 43(5):784-796
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24
Design of Potent Dicyclic (1−5/4−10) Gonadotropin Releasing Hormone (GnRH) Antagonists †

von Rivier, Jean E. ; Jiang, Guangcheng ; Struthers, R. Scott ; et al.

Journal of Medicinal Chemistry. 43(5):807-818
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25
Life Cycle Assessment of Four Floating Wind Farms around Scotland Using a Site-Specific Operation and Maintenance Model with SOVs

von Iain A. Struthers ; Nadezda Avanessova ; Anthony Gray ; et al.

Energies, Vol 16, Iss 23, p 7739 (2023)

Schlagworte: floating wind; life cycle assessment; operation and maintenance; offshore wind; environmental impact; Technology
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