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1
Cost-effectiveness of the CV-polypill strategy versus standard care for secondary cardiovascular prevention in Spain: an analysis based on the SECURE trialResearch in context

von Thomas Gaziano ; José María Castellano ; Amy Dymond ; et al.

The Lancet Regional Health. Europe, Vol 55, Iss , Pp 101348- (2025)

Schlagworte: Cost-effectiveness analysis; Cardiovascular prevention; CV-Polypill; Public aspects of medicine; RA1-1270
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2
Rationale and design of SCOPE trial: a prospective, multicentre, open-label, randomised controlled trial to evaluate the overall efficacy and safety of a short-term anticoagulation strategy versus conventional single antiplatelet therapy in patients with severe aortic stenosis without indications for anticoagulation or dual antiplatelet therapy post-transcatheter aortic valve replacement

von Yang Wang ; Yan Li ; Lihua Zhang ; et al.

BMJ Open, Vol 15, Iss 8 (2025)

Schlagworte: Medicine
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3
Rationale and Design of the CREATE Trial: A Multicenter, Randomized Comparison of Continuation or Cessation of Single Antithrombotic Therapy at 1 Year After Transcatheter Aortic Valve Replacement

von Ran Liu ; Yang Li ; Lihua Zhang ; et al.

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 14, Iss 7 (2025)

Schlagworte: antiplatelet therapy; aortic stenosis; transcatheter aortic valve replacement; treatment withdrawal; Diseases of the circulatory (Cardiovascular) system; RC666-701
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4
Effect of empagliflozin on total myocardial infarction events by type and additional coronary outcomes: insights from the randomized EMPA-REG OUTCOME trial

von David Fitchett ; Bernard Zinman ; Silvio E. Inzucchi ; et al.

Cardiovascular Diabetology, Vol 23, Iss 1, Pp 1-7 (2024)

Schlagworte: Diabetes mellitus; Type 2; Myocardial infarction; Sodium-glucose transporter 2 inhibitors; Diseases of the circulatory (Cardiovascular) system; RC666-701
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5
Totality of evidence of the effectiveness of repurposed therapies for COVID‐19: Can we use real‐world studies alongside randomized controlled trials?

von Jaap Mandema ; Hugh Montgomery ; Louis Dron ; et al.

Clinical and Translational Science, Vol 16, Iss 10, Pp 1842-1855 (2023)

Schlagworte: Therapeutics. Pharmacology; RM1-950; Public aspects of medicine; RA1-1270
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6
Real world safety of methoxyflurane analgesia in the emergency setting: a comparative hybrid prospective-retrospective post-authorisation safety study

von Nawab Qizilbash ; Himanshu Kataria ; Heather Jarman ; et al.

BMC Emergency Medicine, Vol 23, Iss 1, Pp 1-11 (2023)

Schlagworte: Analgesia; Emergency department; Hepatotoxicity; Nephrotoxicity; Safety; Special situations and conditions; RC952-1245; Medical emergencies. Critical care. Intensive care. First aid; RC86-88.9
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7
Comparing the long-term outcomes in chronic coronary syndrome patients with prior ST-segment and non-ST-segment elevation myocardial infarction: findings from the TIGRIS registry

von Satoshi Yasuda ; Christopher B Granger ; David B Brieger ; et al.

BMJ Open, Vol 13, Iss 12 (2023)

Schlagworte: Medicine
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8
Optimising the analysis of vascular prevention trials: Re-Assessment of the TARDIS trial, the first prevention trial to adopt an ordinal primary outcome measure

von Lisa J. Woodhouse ; Alan A. Montgomery ; Stuart Pocock ; et al.

Contemporary Clinical Trials Communications, Vol 35, Iss , Pp 101186- (2023)

Schlagworte: TARDIS; Stroke; Severity; Outcome; Time; Medicine (General); R5-920
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9
Prehospital transdermal glyceryl trinitrate in patients with ultra-acute presumed stroke (RIGHT-2): effects on outcomes at day 365 in a randomised, sham-controlled, blinded, phase III, superiority ambulance-based trial

von Joanna M Wardlaw ; Jeffrey L Saver ; Philip M Bath ; et al.

BMJ Neurology Open, Vol 5, Iss 1 (2023)

Schlagworte: Neurosciences. Biological psychiatry. Neuropsychiatry; RC321-571
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10
Extension Reports in Clinical Trials: A Systematic Review and Consequent Guidance

von Rossello, Xavier ; Pocock, Stuart J. ; Taylor, Dylan ; et al.

In JACC 21 April 2026 87(15):1873-1888
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11
Effect of continuing versus stopping pre-stroke antihypertensive agents within 12 h on outcome after stroke: A subgroup analysis of the efficacy of nitric oxide in stroke (ENOS) trial

von Lisa J. Woodhouse ; Jason P. Appleton ; Polly Scutt ; et al.

EClinicalMedicine, Vol 44, Iss , Pp 101274- (2022)

Schlagworte: Medicine (General); R5-920
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12
A re-examination of the SPYRAL HTN-OFF MED Pivotal trial with respect to the underlying model assumptions

von Michael Böhm ; Martin Fahy ; Graeme L. Hickey ; et al.

Contemporary Clinical Trials Communications, Vol 23, Iss , Pp 100818- (2021)

Schlagworte: Hypertension; Renal denervation; Bayesian; Statistics; Medicine (General); R5-920
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13
Blood cholesterol and risk of dementia in more than 1·8 million people over two decades: a retrospective cohort study

von Masao Iwagami, MD ; Nawab Qizilbash, MRCP ; John Gregson, PhD ; et al.

The Lancet. Healthy Longevity, Vol 2, Iss 8, Pp e498-e506 (2021)

Schlagworte: Geriatrics; RC952-954.6; Medicine
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14
Sex‐Based Differences in Bleeding Risk After Percutaneous Coronary Intervention and Implications for the Academic Research Consortium High Bleeding Risk Criteria

von Alessandro Spirito ; Felice Gragnano ; Noé Corpataux ; et al.

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 12 (2021)

Schlagworte: Academic Research Consortium; bleeding; female sex; percutaneous coronary intervention; vascular access; Diseases of the circulatory (Cardiovascular) system; RC666-701
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15
Serum Magnesium, Outcomes, and the Effect of Empagliflozin in Heart Failure With Mildly Reduced and Preserved Ejection Fraction: Findings From EMPEROR-Preserved

von Ferreira, João Pedro ; Packer, Milton ; Butler, Javed ; et al.

In JACC: Heart Failure February 2026 14(2)
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16
Serum Magnesium and the Effect of Empagliflozin in Heart Failure With Reduced Ejection Fraction: Findings From EMPEROR-Reduced

von Ferreira, João Pedro ; Anker, Stefan D. ; Butler, Javed ; et al.

In JACC: Heart Failure February 2026 14(2)
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17
Beta-blockers after invasively managed STEMI vs NSTEMI without reduced ejection fraction: a prespecified analysis from the REBOOT trial

von Raposeiras-Roubín, Sergio ; Anguita, Manuel ; Latini, Roberto ; et al.

In Revista Española de Cardiología (English Edition) March 2026
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18
Empagliflozin in Heart Failure and Previous Coronary Revascularization: Insights From EMPEROR-Pooled

von Dhingra, Nitish K. ; Butler, Javed ; Anker, Stefan D. ; et al.

In JACC: Advances January 2026 5(1)
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19
Relationship between nitrate headache and outcome in patients with acute stroke: results from the efficacy of nitric oxide in stroke (ENOS) trial

von Lucy Beishon ; Joanna Wardlaw ; Stuart Pocock ; et al.

Stroke and Vascular Neurology, Vol 6, Iss 2 (2021)

Schlagworte: Neurology. Diseases of the nervous system; RC346-429
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20
Spironolactone versus placebo in patients undergoing maintenance dialysis (ACHIEVE): an international, parallel-group, randomised controlled trial

von Devereaux, PJ ; Walsh, Michael ; Arici, Mustafa ; et al.

In The Lancet 16-22 August 2025 406(10504):695-704
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21
Central masked adjudication of stroke diagnosis at trial entry offered no advantage over diagnosis by local clinicians: Secondary analysis and simulation

von Peter J. Godolphin ; Trish Hepburn ; Nikola Sprigg ; et al.

Contemporary Clinical Trials Communications, Vol 12, Iss , Pp 176-181 (2018)

Schlagworte: Medicine (General); R5-920
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22
Vascular complications in patients with type 2 diabetes: prevalence and associated factors in 38 countries (the DISCOVER study program)

von Mikhail Kosiborod ; Marilia B. Gomes ; Antonio Nicolucci ; et al.

Cardiovascular Diabetology, Vol 17, Iss 1, Pp 1-13 (2018)

Schlagworte: Type 2 diabetes; Vascular complications; Observational study; Diseases of the circulatory (Cardiovascular) system; RC666-701
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23
Changes in HbA1c and weight, and treatment persistence, over the 18 months following initiation of second-line therapy in patients with type 2 diabetes: results from the United Kingdom Clinical Practice Research Datalink

von John Wilding ; Thomas Godec ; Kamlesh Khunti ; et al.

BMC Medicine, Vol 16, Iss 1, Pp 1-12 (2018)

Schlagworte: Clinical practice research datalink (CPRD); Dipeptidyl peptidase-4 inhibitor (DPP-4 inhibitor); HbA1c; Metformin; Second-line therapy; Sodium-glucose cotransporter 2 inhibitor (SGLT-2 inhibitor); Medicine
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24
Health-related quality of life 1–3 years post-myocardial infarction: its impact on prognosis

von Satoshi Yasuda ; Christopher B Granger ; David B Brieger ; et al.

Open Heart, Vol 8, Iss 1 (2021)

Schlagworte: Diseases of the circulatory (Cardiovascular) system; RC666-701
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25
β blockers after myocardial infarction with mildly reduced ejection fraction: an individual patient data meta-analysis of randomised controlled trials

von Rossello, Xavier ; Prescott, Eva Irene Bossano ; Kristensen, Anna Meta Dyrvig ; et al.

In The Lancet 13-19 September 2025 406(10508):1128-1137
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