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1
Omadacycline versus moxifloxacin for community-acquired bacterial pneumonia (OPTIC-2): a phase 3b, randomised, double-blind, multicentre, controlled, noninferiority trialResearch in context

von Thomas M. File, Jr. ; Keith S. Kaye ; Skliarov Ihor ; et al.

EClinicalMedicine, Vol 90, Iss , Pp 103656- (2025)

Schlagworte: Community-acquired pneumonia; Aminomethylcycline; Tetracycline; Postmarketing; Antimicrobial resistance; Medicine (General); R5-920
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2
Vaccines and Other Preventative Strategies for Immunocompromised Pneumonia

von File, Thomas M., Jr.

In Clinics in Chest Medicine March 2025 46(1):21-35
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3
Pooled microbiological findings and efficacy outcomes by pathogen in adults with community-acquired bacterial pneumonia from the Lefamulin Evaluation Against Pneumonia (LEAP) 1 and LEAP 2 phase 3 trials of lefamulin versus moxifloxacin

von Paukner, Susanne ; Goldberg, Lisa ; Alexander, Elizabeth ; et al.

In Journal of Global Antimicrobial Resistance June 2022 29:434-443
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4
Safety and efficacy of omadacycline for treatment of community-acquired bacterial pneumonia and acute bacterial skin and skin structure infections in patients with mild-to-moderate renal impairment

von Cornely, Oliver A. ; File, Thomas M., Jr. ; Garrity-Ryan, Lynne ; et al.

In International Journal of Antimicrobial Agents February 2021 57(2)
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5
The Role of Antibiotic Stewardship and Telemedicine in the Management of Multidrug-Resistant Infections

von File, Thomas M., Jr. ; Jump, Robin L.P. ; Goff, Debra A.

In Infectious Disease Clinics of North America December 2020 34(4):903-920
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6
Surveillance of iclaprim activity: in vitro susceptibility of Gram-positive skin infection pathogens collected from 2015 to 2016 from North America and Europe

von Huang, David B ; Magnet, Sophie ; De Angelis, Stefania ; et al.

In Diagnostic Microbiology & Infectious Disease February 2019 93(2):154-158
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7
Lefamulin efficacy and safety in a pooled phase 3 clinical trial population with community-acquired bacterial pneumonia and common clinical comorbidities

von Thomas M. File ; Elizabeth Alexander ; Lisa Goldberg ; et al.

BMC Pulmonary Medicine, Vol 21, Iss 1, Pp 1-10 (2021)

Schlagworte: Antibiotic; Clinical response; Lefamulin; Pleuromutilin; Pneumonia; Diseases of the respiratory system; RC705-779
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8
Pooled analysis of the phase 3 REVIVE trials: randomised, double-blind studies to evaluate the safety and efficacy of iclaprim versus vancomycin for treatment of acute bacterial skin and skin-structure infections

von Huang, David B. ; Corey, G. Ralph ; Holland, Thomas L. ; et al.

In International Journal of Antimicrobial Agents August 2018 52(2):233-240
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9
Surveillance of iclaprim activity: In vitro susceptibility of gram-positive pathogens collected from 2012 to 2014 from the United States, Asia Pacific, Latin American and Europe

von Huang, David B. ; File, Thomas M., Jr. ; Dryden, Matthew ; et al.

In Diagnostic Microbiology & Infectious Disease April 2018 90(4):329-334
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10
The risk of prescribing antibiotics “just-in-case” there is infection

von Goff, Debra A. ; File, Thomas M., Jr

In Seminars in Colon and Rectal Surgery March 2018 29(1):44-48
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11
The effect of pulmonary surfactant on the in vitro activity of Iclaprim against common respiratory bacterial pathogens

von Huang, David B. ; Duncan, Leonard R. ; Flamm, Robert K. ; et al.

In Diagnostic Microbiology & Infectious Disease January 2018 90(1):64-66
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12
Bacterial Pneumonia in Older Adults

von Marrie, Thomas J. ; File, Thomas M., Jr.

In Clinics in Geriatric Medicine August 2016 32(3):459-477
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13
A Phase II Randomized, Double-blind, Multicenter Study to Evaluate Efficacy and Safety of Intravenous Iclaprim Versus Vancomycin for the Treatment of Nosocomial Pneumonia Suspected or Confirmed to be Due to Gram-positive Pathogens

von Huang, David B. ; File, Thomas M., Jr ; Torres, Antoni ; et al.

In Clinical Therapeutics August 2017 39(8):1706-1718
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14
Lefamulin in Patients with Community-Acquired Bacterial Pneumonia Caused by Atypical Respiratory Pathogens: Pooled Results from Two Phase 3 Trials

von Susanne Paukner ; David Mariano ; Anita F. Das ; et al.

Antibiotics, Vol 10, Iss 1489, p 1489 (2021)

Schlagworte: atypical pathogens; lefamulin; community-acquired bacterial pneumonia; Mycoplasma pneumoniae; Chlamydia pneumoniae; Legionella pneumophila; Therapeutics. Pharmacology; RM1-950
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15
Nosocomial (Health Care–Associated) Legionnaire's Disease

von Agarwal, Shanu ; Abell, Virginia ; File, Thomas M., Jr.

In Infectious Disease Clinics of North America March 2017 31(1):155-165
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16
The Evolving Role of Antimicrobial Stewardship in Management of Multidrug Resistant Infections

von Goff, Debra A. ; File, Thomas M., Jr.

In Infectious Disease Clinics of North America June 2016 30(2):539-551
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17
A proteomics and redox proteomics approach to understanding ARDS heterogeneity

von Thomas E. Forshaw ; Kirtikar Shukla ; Hanzhi Wu ; et al.

Scientific Reports, Vol 16, Iss 1 (2026)

Schlagworte: Medicine; Science
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18
Building an international precision medicine platform trial for the acute respiratory distress syndrome (ARDS): an expert consensus project report

von Kiran Reddy ; Neil Aggarwal ; Narges Alipanah-Lechner ; et al.

Efficacy and Mechanism Evaluation (2025)

Schlagworte: acute respiratory distress syndrome; platform trials; precision medicine; biomarker-guided trials; intensive care; critical care; airway extubation; algorithms; biological specimen banks; biological variation; population; biomarkers; covid-19; clinical trials; phase ii as topic; cluster analysis; critical illness; cytokines; intensive care units; intubation; intratracheal; logistic models; noninvasive ventilation; outcome assessment; health care; pandemics; phenotype; pneumonia; randomized controlled trials as topic; reproducibility of results; respiration; artificial; respiratory distress syndrome; respiratory insufficiency; sepsis; simvastatin; Medicine
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19
Validation of a Novel, Rapid Sepsis Diagnostic for Emergency Department Use

von Hollis R. O’Neal, Jr, MD, MSc ; Roya Sheybani, PhD ; David R. Janz, MD, MSc ; et al.

Critical Care Explorations, Vol 6, Iss 2, p e1026 (2024)

Schlagworte: Medical emergencies. Critical care. Intensive care. First aid; RC86-88.9
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20
Trend in Clinical Trial Participation During COVID-19: A Secondary Analysis of the I-SPY COVID Clinical Trial

von Philip Yang, MD, MSc ; Neal W. Dickert, MD, PhD ; Angela Haczku, MD, PhD ; et al.

Critical Care Explorations, Vol 5, Iss 6, p e0930 (2023)

Schlagworte: Medical emergencies. Critical care. Intensive care. First aid; RC86-88.9
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21
Report of the first seven agents in the I-SPY COVID trial: a phase 2, open label, adaptive platform randomised controlled trialResearch in context

von D. Clark Files ; Neil Aggarwal ; Timothy Albertson ; et al.

EClinicalMedicine, Vol 58, Iss , Pp 101889- (2023)

Schlagworte: SARS-CoV-2; Respiratory insufficiency; Clinical trial; Acute lung injury; Medicine (General); R5-920
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22
Does Empiric Therapy for Atypical Pathogens Improve Outcomes for Patients with CAP?

von File, Thomas M., Jr. ; Marrie, Thomas J.

In Infectious Disease Clinics of North America March 2013 27(1):99-114
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23
I-SPY COVID adaptive platform trial for COVID-19 acute respiratory failure: rationale, design and operations

von Carolyn S Calfee ; Michael A Matthay ; Paul Henderson ; et al.

BMJ Open, Vol 12, Iss 6 (2022)

Schlagworte: Medicine
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24
Photobleaching studies reveal that a single amino acid polymorphism is responsible for the differential binding affinities of linker histone subtypes H1.1 and H1.5

von Thomas W. Flanagan ; Jacob K. Files ; Kelsey Rose Casano ; et al.

Biology Open, Vol 5, Iss 3, Pp 372-380 (2016)

Schlagworte: Histone H1; Linker histone; Chromatin; FRAP; Science; Biology (General); QH301-705.5
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25
Mycoplasma pneumoniae Pneumonia

von File, Thomas M., Jr. ; Tan, James S. ; Marrie, Thomas J., editor

Community-Acquired Pneumonia. :487-500
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